A 79-year-old British Columbia man’s dead after failing to negotiate a curve while riding a motorcycle in Okanogan County Saturday.Frank M. Hurney was traveling eastbound on SR 20 21 miles east of Mazama when the incident occurred. The man, who was wearing a helmet, was pronounced dead at the scene.It’s not known if drugs or alcohol were involved. State Patrol is investigating the cause of the accident.
42 percent of caregivers use in-person support groups, online communities/forums 55 percent of caregivers say they are not getting adequate emotional support May 31 2018Nearly two-thirds of caregivers whose loved ones suffer from the debilitating effects of Alzheimer’s or related dementia say they would take medication to delay the onset of their own memory loss by even six months, if it were affordable and free of side effects. Sixty-four percent say they’ve already made healthy lifestyle modifications in an effort to prevent their own memory loss, making meaningful edits to their diet and exercise. However, only one-third of caregivers say they have been tested for the Alzheimer’s gene. These, and other, findings were revealed in a new report from Healthline Media, the fastest growing health information brand, reaching 39 million monthly users in the United States.The report, “State of Caregiving for Alzheimer’s Disease and Related Dementia 2018,” examines the current caregiving population, the challenges they face in caring for a loved one with the disease today and how advances in science and technology may affect caregiving roles in the future. The report included a survey of nearly 400 active caregivers across generations and in-depth interviews with medical experts and advocacy groups. The full report can be accessed at www.healthline.com/health/state-of-alzheimers.”Alzheimer’s disease is on the rise, and the landscape is evolving – the types of clinical trials, treatments, resources/support, and the accelerated need for more family caregivers to take on the intensive responsibility of care for loved ones,” said Diane Ty, Project Director of the Global Social Enterprise Initiative and AgingWell Hub at Georgetown University’s McDonough School of Business. “Healthline’s report helps prepare the modern patient and caregiver for the new state of Alzheimer’s disease and other dementias.”According to Healthline’s report, the intimate view of a loved one aging with Alzheimer’s or related dementia is prompting more caregivers (34 percent) to be genetically tested for the disease, something millennials (49 percent) are more proactive about than older generations (Gen Xers 36 percent, Boomers 17 percent.)Most caregivers report that a specific incident prompted a medical evaluation for their loved one (70 percent.) In almost half of all cases the incident was the last in a series, though more than one quarter of the cases were the first of its kind. Interestingly, millennial caregivers were more likely to report a first-time incident led to a medical evaluation (41 percent) compared to other caregiver groups (Boomers 21 percent; Gen Xers 18 percent.)Related StoriesNanoparticles used to deliver CRISPR gene editing tools into the cellResearchers discover new therapeutic target for treatment of Alzheimer’s diseaseResearchers develop a more precise version of CRISPR-Cas9 gene-editing systemKey Findings: CAREGIVER RESOURCES PATIENT 67 percent take up to one year to receive a specific diagnosis 41 percent had MCI (mild cognitive impairment) before an Alzheimer’s or related dementia diagnosis 75 percent of Alzheimer’s or related dementia patients remain home or in a private residence despite the disease’s progression CAREGIVER 71 percent of caregivers are female 72 percent of caregivers say their health has worsened since becoming caregivers 1 of 2 caregivers have had their career and/or finances impacted due to caregiving responsibilities “We know our readers – both patients and their caregivers – have individual health journeys and we always strive to understand their specific paths, and how our content can best support them,” said Tracy Stickler, Editor in Chief, Healthline. “The latest “State of…” report helps deepen our understanding of the evolving needs of the caregiver so we can create content and programs to better support them in making critical decisions.Healthline’s “State Of…” series examines consumer lifestyle data gathered by the website’s research team. “State of…” research results are paired with editorial content illustrating topics from the consumer’s perspective, highlighting credible, expert-informed insights to inform health decisions. The “State of…” series kicked off in July 2017 with the “State of Fertility,” followed by the “State of Care” and “State of Cancer.” “State of Caregiving for Alzheimer’s Disease and Related Dementia 2018” adds to the growing body of research in key disease states affecting Healthline’s readers – the modern healthcare consumer and their caregivers. Additional studies in this series will continue in 2018, examining other key disease states affecting Healthline’s readers.Source: https://www.healthline.com/
Jun 21 2018Oxidative stress can help tumors thrive, but one way novel cancer treatments work is by pushing levels to the point where it instead helps them die, scientists report.Adoptive T cell therapy appears to reprogram the metabolism of tumor cells, increasing their level of reactive oxygen species, or ROS, and their destruction, says Dr. Gang Zhou, immunologist at the Georgia Cancer Center and Department of Medicine at the Medical College of Georgia at Augusta University.Scientists treated mice that had large, localized colorectal tumors with adoptive T cell therapy after preconditioning them with a chemotherapy drug known to help with the expansion and persistence of these infused T cells. The T cells are a patient’s own cells, but engineered to better fight cancer.The therapy appeared to deliver a deadly double-whammy to the cancer cells, says Zhou, corresponding author of the study in the journal Cell Metabolism.The scientists found the treatment interfered with production of glutathione, a natural antioxidant found in all cells, as it heightened production and accumulation of ROS inside tumor cells.Results included increased production by T cells of proinflammatory cytokines – including tumor necrosis factor alpha – which regulate many functions cancer needs to control like cell proliferation, differentiation and death.”We started by asking questions about how immunotherapy can change the metabolism of tumor cells. Our studies show tumor necrosis factor alpha can act directly on tumor cells and induce ROS inside them,” Zhou says.The bottom line of the metabolic changes include, for example, complete tumor regression in nearly all the tested mice.The scientists found similar effects – higher ROS levels correlated with high tumor cell death – when the therapy was used in models of breast cancer and lymphoma.Tumor necrosis factor alpha appears key to these desired results following adoptive T cell therapy, because when the scientists eliminated it from the equation, tumor cell death decreased dramatically.Scavenging ROS had a similar effect. When they gave the antioxidant N-acetylcysteine – a precursor to glutathione – it also hampered the curative effect of adoptive T cell therapy, they report.They also found that tumor necrosis factor alpha synergizes with chemotherapy to increase oxidative stress and cancer cell death. And, that giving pro-oxidants – drugs known to raise ROS levels – can somewhat replicate the tumor-killing benefit of adoptive T cell therapy. It’s known that these drugs may increase oxidative stress in cancer cells and push them toward death, or apoptosis, Zhou says.Related StoriesResearchers identify potential drug target for multiple cancer typesLiving with advanced breast cancerHow cell-free DNA can be targeted to prevent spread of tumors”Their baseline is already high and if you further disrupt their ability to deal with these free radicals, they will go toward apoptosis,” Zhou says.In fact, in an apparent failed attempt to fight off the higher ROS, the scientists found increased expression of several antioxidant genes in treated tumor cells.The significant, cancer-lethal ROS increases they found were limited to the tumor cells, not other nearby cell types.The scientists note that the direct killing of tumors by ROS they saw does not negate the possibility that tumor necrosis factor alpha also is working through its previously known method of killing off blood supplies to tumors.Antioxidant therapy in patients with active cancer has drawn mixed results, but most studies indicate that it worsens cancer, particularly in smokers, according to the National Cancer Institute. Preclinical studies in mice indicate the therapy promotes tumor growth and metastasis. Studies exploring the benefit of antioxidant therapy in preventing cancer have largely shown no benefit or harm, the NCI says.Tumors are known to impact T cells. In fact scientists have shown that the two can compete for nutrition and energy in the tumor microenvironment, remote sites tumors establish to successfully spread, the scientists write. It’s T cells that usually get short shrift in the struggle.Comparatively little focus has been on what T cells do to tumors, Zhou and his colleagues report. But better understanding of that impact should help improve immunotherapies, like adoptive T cell therapy, that seek to enable T cells to better target tumors.Adoptive T cell therapy is still under development for treatment of colorectal cancer. This therapeutic approach was already known to essentially poke holes in cancer cells to kill them.ROS are chemicals like peroxide and superoxide that are byproducts of necessary body functions like the use of oxygen and energy production by cell powerhouses called mitochondria. One reason cancer cells have naturally higher ROS levels is they have a high energy demand, Zhou says, constantly working to grow and spread.Some level of ROS also benefits our healthy cells, including cell proliferation and differentiation. But, too much is also deadly to normal cells, even damaging to DNA.Source: https://www.augusta.edu/mcg/
Reviewed by James Ives, M.Psych. (Editor)Aug 28 2018A new report led by King’s and published by the government’s Committee on the Medical Effects of Air Pollutants (COMEAP) estimates that between 28,000 and 36,000 people die as a result of air pollution every year in the UK. This is a significant increase on their 2015 figure of about 29,000.The committee, chaired by Professor Frank Kelly, School of Population Health & Environmental Sciences, looked primarily at nitrogen dioxide and fine particulate pollution which are produced when petrol or other fuels are burnt. They highlighted that although this was the focus of their analysis, estimates of the number of deaths would inevitably include the effects of other pollutants that occur simultaneously such as ultrafine particles, polycyclic aromatic hydrocarbons and volatile organic compounds.Related StoriesResearchers explore connection between sense of smell, pollution and neurological diseaseIncreased air pollution could reduce health benefits of living in walkable neighborhoodsResearch finds link between air pollution and coronary heart disease in ChinaProlonged exposure to these chemicals can exacerbate respiratory conditions and has been associated with a range of other health problems. Young children and older adults are particularly vulnerable.COMEAP’s report proposes that reducing the amount of traffic pollutants in the air we breathe* would save the UK population about 1.6 million life years over the next 106 years: equivalent to an increase of life expectancy at birth of eight days each.Professor Kelly, COMEAP Chairman and Director of King’s Environmental Research Group (ERG), said of the committee’s findings: Source:https://www.kcl.ac.uk/lsm/schools/population-health-and-environmental-sciences/newsrecords/air-pollution-could-cause-36000-deaths-a-year-in-the-uk.aspx ‘COMEAP’s latest report sought to gain a better understanding of the links between nitrogen dioxide and health and potentially provide a more complete overall picture of the health impact of air pollution.In London, the ERG has been highlighting the nitrogen dioxide problem for some time now and as increased control measures are introduced to deal with the issue we are undertaking studies to help monitor the benefit of decreased emissions and improved air quality on health.’
BREAKING: missing 4YO Maleah Davis was removed from her home in August by CPS. They tell us it was due to allegations of physical abuse, related to Maleah’s head injury, which required several brain surgeries. She was returned home in Feb. @abc13houston pic.twitter.com/jiAq1E6XVU— Shelley Childers (@shelleyabc13) May 6, 2019 The Associated Press reported that Houston authorities said Vence’s account has “changed several times.”Maleah was reportedly last seen wearing a pink bow in her hair with a light blue zip-up jacket, blue jeans and gray, white and pink sneakers. She has black hair and brown eyes and stands 3 feet tall, weighing 30 to 40 pounds.SEE ALSO:All The Ways Cops Are Still Trying To Cover Up LaQuan McDonald’s ExecutionOutrageous! Figurines Of White Cherub Crushing Head Of Black Angel Removed From Dollar StoreMeet Jogger Joe, The Man Who Took Racist Cue From BBQ Becky In Tossing Homeless Man’s Clothes Bowens actually responded with, “No not yet until I find out.”Her Instagram appears to now be deleted or private.Although has said she was “not sure” if there was abuse in her home, Texas Child Protective Services reportedly removed Maleah from Bowens’ home last year “due to allegations of physical abuse” that “required several surgeries,” ABC reporter Shelley Childers tweeted earlier this month. Brittany Bowens , Derion Vence , Maleah Davis Jesse Jackson Demands ‘Justice Now’ At EJ Bradford’s Moving Funeral Ceremony AddThis Sharing ButtonsShare to FacebookFacebookFacebookShare to TwitterTwitterTwitterShare to MoreAddThisMoreShare to EmailEmailEmail Four-year-old Maleah Davis has been missing for nearly three weeks and Derion Vence, her stepfather, is the sole “person of interest.” However, there were questions surrounding Maleah’s mother, Brittany Bowens, the latest of which stem from her social media habits. In particular, Bowens was slammed for keeping photos of Vence on her Instagram.See Also: A Timeline Of Dallas Cop Amber Guyger Killing Botham Jean In His Own HomeThere were photos and even a video of Vence next to Bowens’ five Instagram posts about Maleah, according to Fox 26. Users were outraged and left comments saying so. “You might want to delete Derion’s pictures off here, don’t you think?” on person wrote. “Please tell me why a man involved with the disappearance of Maleah won’t be deleted off your page,” another said. Meghan McCain Whines That She Can’t Attack llhan Omar Because Trump Is Too Racist More By NewsOne Staff A$AP Rocky Being In A Swedish Prison Will Not Stop Her From Going To The Country That Showed Her ‘So Much Love’ There has been speculation that Bowens may have something to do with her daughter’s disappearance. Vence’s father recently pointed fingers at Bowens and claimed his son was being set up.Vence originally told Sgt. Mark Holbrook of the Houston Police Department’s Homicide Division that he, Maleah and his two-year-old son were on their way to George Bush Intercontinental Airport Friday night to pick up Maleah’s mother, who was flying in from Massachusetts. Vence said he heard a “popping noise” and pulled over. He said a blue pickup truck pulled up behind his vehicle and two Hispanic males got out and hit him in the head. He said he lost consciousness and woke up at 6 p.m. the next day. He said Maleah was missing but his son was still there. Vence claimed he then walked to a hospital, received treatment and then reported Maleah as missing. Gov. Cuomo Slams Mayor Bill De Blasio For The Eric Garner Case But He Also Failed The Family
35 Positive Images Of Black Dads That Shatter False Stereotypes On Father’s Day Aisha Harper , Dravion Ames , Jay Z , Phoenix Police Department Entertainment, News and Lifestyle for Black America. News told by us for us. Black America’s #1 News Source: Our News. Our Voice. White Tears! Former Meteorologist Files Lawsuit Claiming He Was Fired Because Of Diversity More By Megan Sims “You’re gonna fucking get shot!” the cop yells at one point.“I’m gonna put a fucking cap in your fucking head,” he said in another instance. SUBSCRIBE “My hands are up! My hands are up!” 22yo Dravon Ames says as a Phoenix police officer yells to “get your fucking hands up.” The same officer later says “You’re gonna fucking get shot!”Ames says the officers stopped him after his child walked out of a Dollar Store with a doll. pic.twitter.com/Nlkd7IXsyc— Meg O’Connor (@megoconnor13) June 12, 2019Meyer also pointed a gun at the group threatening to shoot them and demanding Harper put her baby on the hot ground despite the fact she could not walk. And all of this because a four-year-old allegedly took a 99 cent doll.On Saturday, ABC15 obtained a copy of the full police report, which was written by Meyer and found there were major differences in what was seen on the video and what was written in the report. The news outlet reported that Meyer made no mention of holding the family at gunpoint only writing that “Iesha was then removed from the vehicle.” He also did not talk about how he kicked Ames in the leg while he was handcuffed, which he only stated that Ames “began to tense his arms and turn back towards me. I made him spread his feet.” Another glaring omission was found when Meyer failed to mention that he ordered to put her child on the ground as he claimed Harper “refused to put the child down. She became loud, verbally abusive and refused our commands.” Another angle of the incident filmed by a different resident of the apartment complex where Ames and his pregnant fiancee were dropping off their kids with a babysitter show a Phoenix police officer trying to yank the child from the mother’s arms. pic.twitter.com/pTb07lZAXD— Meg O’Connor (@megoconnor13) June 12, 2019Following the massive outrage, Jay-Z‘s philanthropic organization within his entertainment company ROC Nation offered to provide legal support to Ames and Harper, who filed a claim on Thursday demanding $10 million from the city of Phoenix. According to AZCentral, ROC secured high-profile attorney Alex Spiro and is demanding the termination of the police officers involved and plan on filing against one of the officers for child neglect.“There is no place for that behavior in our world – let alone our justice system – and we are calling for the immediate termination of the police officers in question,” ROC Nation Managing Director of Philanthropy Dania Diaz said. “We are committed to supporting the family to ensure that justice is served.”Phoenix Police Chief Jeri Williams, who is a Black woman, released a video on the department’s Facebook page on Friday saying she was “disturbed by the language and actions of our officer.” Williams had to release another video prior to this incident after a new database outed racist Facebook posts made by police officers around the country, many of whom were with the Phoenix Police Department. Viral video of a rogue police officer pointing a gun at a Black family in the presence of an infant and a young child in Phoenix, Arizona, angered countless people around the country. Newly released police documents show that the cop involved was not completely honest in his report on the incident. Now one hip-hop legend is lending a hand to the family in a major way as they begin the process of seeking justice. Morehouse Students Take To Social Media And Claim Sexual Harassment Complaints Were Ignored Jamaican Republican Who Is Running Against AOC Supported Her A Year Ago Witness video of the May 29 incident shows Phoenix police officer Christopher Meyer screaming threats and profanity toward a Black family in a van that contained Dravon Ames, 22, his pregnant fiance Aisha Harper, 24, their two young daughters. Thanks for signing up! Get ready for Exclusive content, Interviews,and Breaking news delivered direct to your inbox. Get ready for Exclusive content, Interviews,and Breaking news delivered direct to your inbox. A check of the database did not bring up results for Meyer, who is currently being reviewed by the Phoenix Police Department’s Professional Standards Bureau.SEE ALSO:Sudan Is Burning But People Don’t Care Because It’s Not A CathedralBlack Teacher Gives Students Haircuts For Graduation
“It is the assessment of the United States government that the Islamic Republic of Iran is responsible for the attacks that occurred in the Gulf of Oman today,” US Secretary of State Mike Pompeo.Pompeo did not provide explicit evidence to back up the US assertion.“This assessment is based on intelligence, the weapons used, the level of expertise needed to execute the operation, recent similar Iranian attacks on shipping, and the fact that no proxy group operating in the area has the resources and proficiency to act with such a high degree of sophistication,” Pompeo said.Iran “categorically rejects the US unfounded claim with regard to 13 June oil tanker incidents and condemns it in the strongest possible terms,” the Iranian mission to the United Nations said in a statement on Thursday evening. An oil tanker is seen after it was attacked at the Gulf of Oman, June 13, 2019. (ISNA/Handout via Reuters)The United States blamed Iran for attacks on two oil tankers in the Gulf of Oman on Thursday that drove up oil prices and raised concerns about a new US-Iranian confrontation, but Tehran bluntly denied the allegation. LiveKarnataka floor test: Will Kumaraswamy’s 14-month-old govt survive? Related News The tanker attack will not affect Japanese energy supply, Japanese Industry Minister Hiroshige Seko said, although the ministry issued a warning to Japanese energy companies.Crude oil prices spiked more than 4% after the attacks near the entrance to the Strait of Hormuz, a crucial shipping artery for Saudi Arabia and other Gulf energy producers. Prices later settled about 2% higher. Brent crude was down by 0.4% at $61.06 a barrel in early Asia trading.Explained: How tanker attackers on a skinny waterway could affect oil pricesThe United States, which has accused Iran or its proxies of carrying out a May 12 attack on four tankers off the United Arab Emirates’ coast as well as May 14 drone strikes on two Saudi oil-pumping stations, squarely blamed Iran for Thursday’s attacks. It was not immediately clear what befell the Norwegian-owned Front Altair or the Japanese-owned Kokuka Courageous, which both experienced explosions, forcing crews to abandon ship and leave the vessels adrift in waters between Gulf Arab states and Iran.One source said the blast on the Front Altair, which caught fire and sent a huge plume of smoke into the air, may have been caused by a magnetic mine. The firm that chartered the Kokuka Courageous tanker said it was hit by a suspected torpedo, but a person with knowledge of the matter said torpedoes were not used.On Thursday night, US Central Command spokesman Bill Urban released a video of what the US military said was an Iranian Revolutionary Guard Corp Gashti Class patrol boat approaching the Kokuka Courageous “and was observed and recorded removing (an) unexploded limpet mine from the M/T Kokuka Courageous.” Best Of Express Iran said it would not respond to Trump’s overture, the substance of which was not made public. Advertising Hassan Rouhani says Iran ready to talk to US if sanctions lifted More Explained Advertising Kulbhushan Jadhav ‘guilty of crimes’, will proceed further as per law: Imran Khan Virat Kohli won’t have a say in choosing new coach By Reuters |Dubai, Washington | Updated: June 14, 2019 12:21:29 pm Advertising Post Comment(s) Taking stock of monsoon rain With Iran deal teetering on brink, Europeans assess next steps UK says seized Iranian oil tanker could be released It accused the United States and its regional allies, which include Iranian rival Saudi Arabia and the United Arab Emirates, of “warmongering.” Iran called on “the international community to live up to its responsibilities in preventing the reckless and dangerous policies and practices of the US and its regional allies in heightening the tensions in the region.”US and European security officials as well as regional analysts cautioned against jumping to conclusions about who carried out the attacks, leaving open the possibility that Iranian proxies, or someone else entirely, might have been responsible.In London, British Foreign Secretary Jeremy Hunt said the UK was taking the matter “extremely seriously” and that if Iran was involved, “it is a deeply unwise escalation which poses a real danger to the prospects of peace and stability in the region.”‘Suspicious’ Tensions between Iran and the United States have risen since US President Donald Trump pulled out of a deal last year between Iran and global powers that aimed to curb Tehran’s nuclear ambitions in exchange for sanctions relief.Iran has repeatedly warned it would block the Strait of Hormuz if it cannot sell its oil because of US sanctions.Tensions have increased further since Trump acted at the beginning of May to force Iran’s oil customers to slash their imports to zero or face draconian US financial sanctions. Iran’s oil exports have dropped to around 400,000 barrels per day in May from 2.5 million bpd in April last year.Also in May, the Trump administration said it would send more troops to the Middle East, citing what it saw as a threat of potential attack by Iran.Iranian Foreign Minister Mohammad Javad Zarif described the tanker explosions as “suspicious” on Twitter and called for regional dialogue. In a later Twitter post, Zarif described the US allegations against Iran as part of “sabotage diplomacy.”Tehran has denied responsibility for the May 12 attacks.The crews of both ships struck on Thursday were picked up safely. The Bahrain-based US Navy Fifth Fleet said it had assisted the two tankers after receiving distress calls.UN Secretary-General Antonio Guterres told a meeting of the Security Council on cooperation between the United Nations and the League of Arab States that the world could not afford “a major confrontation in the Gulf region”.The Security Council discussed the attacks behind closed doors on Thursday at the request of the United States.Kuwait’s UN ambassador, Mansour Al-Otaibi, president of the council for June, said after the meeting that all 15 council members had condemned the attacks.When asked if the United States had shown any evidence to support its accusation that Iran was responsible, Al-Otaibi told reporters: “We didn’t discuss any evidence.”Iran, US say war should be avoided Both Iran and the United States have said they want to avoid war.“Iran will never initiate a war but will give a crushing response to any aggression,” Iranian President Hassan Rouhani said on Wednesday.US Central Command said in a statement on Thursday evening that “we have no interest in engaging in a new conflict in the Middle East. We will defend our interests, but a war with Iran is not in our strategic interest, nor in the best interest of the international community.”Pompeo said US policy remained making economic and diplomatic efforts to bring Iran back to negotiations on a broader deal.The Iranian UN mission’s statement said: “It is ironic that the US who unlawfully withdrew from the Joint Comprehensive Plan of Action now calls Iran to come back to negotiations and diplomacy,” using the formal name of the 2015 nuclear accord.In abandoning the deal, Trump made clear he wanted Iran to curb not merely its nuclear work but its development of missiles and support for proxy forces in Iraq, Syria, Lebanon and Yemen.Some regional analysts said they thought the attacks were likely to have been carried out by Iran and described them as a way for Tehran to try to acquire negotiating leverage and perhaps increase global pressure for US-Iran talks.“There is always the possibility that somebody is trying to blame the Iranians,” said Jon Alterman of Washington’s Center for Strategic and International Studies.“But there is the greater likelihood that this represents an effort to bolster Iranian diplomacy by creating a perceived international urgency to have the United States and Iran talk,” Alterman said.Japanese Prime Minister Shinzo Abe was visiting Tehran when Thursday’s attacks occurred, carrying a message for Iran from Trump. Abe, whose country was a big importer of Iranian oil until Trump ratcheted up sanctions, urged all sides not to let tensions increase.
Afghan radio station closes down following Taliban threats Despite Afghan-Taliban peace talks, war on civilians continue Related News An injured man receives treatment at the hospital, after a suicide attack in Jalalabad, Afghanistan. (REUTERS)A 13-year-old suicide bomber blew himself up at a wedding in eastern Afghanistan’s Nangarhar province, killing five people and injuring 11 others. Advertising By AP |Kabul | Published: July 12, 2019 1:46:28 pm Taliban car bomb kills at least 12 in attack on Afghan security compound Police official Fayz Mohammad Babarkhil said the child blew himself up early Friday at a wedding organized by Malik Toor, a commander of a pro-government militia.Toor died in the attack, and officials said he was the likely target of the bomber. The attack took place in Pachirwa Agham district of Nangarhar province.No one took responsibility for the attack, but both the Taliban and the Islamic State affiliate have a strong presence in eastern Afghanistan, and the IS group is headquartered in Nangarhar province. 1 Comment(s)
Source:https://news.stanford.edu/2018/12/12/watching-brain-cells-fire-real-time/ Reviewed by James Ives, M.Psych. (Editor)Dec 14 2018Scientists have plenty of ways to watch as individual neurons in a brain fire, sending electrical signals from one to the next, but they all share a basic problem. Each method, whether it involves electrical probes, chemical agents or genetic modifications, is in some way more invasive than neuroscientists would like.That may soon change. As Stanford researchers report Dec. 12 in Light: Science and Applications, they have developed a way to watch brain cells send electrical signals using only light, a few lenses and other optical elements, and a fast video camera.The key to the new approach, said Daniel Palanker, a professor of ophthalmology and senior author on the new paper, is that when neurons fire electrical signals they subtly change shape. That nanometer-scale change can be measured using optical techniques.So far, Palanker, Tong Ling, a postdoctoral fellow and the lead author on the new paper, and colleagues have measured those miniscule shape changes in networks of neuron-like cells in a lab dish. They are now adapting their methods to study neurons in the brains of living animals. If that works out, it could lead to a more natural way to study at least some parts of the brain.”It’s all natural, no chemical markers, no electrodes, nothing. It’s just cells as they are,” said Palanker, who is a member of Stanford Bio-X and the Wu Tsai Neurosciences Institute.The shape of thingsA lot goes on when neurons fire. There is of course the electrical signal itself, which can be picked up by electrodes. There are also chemical changes, which can be detected using fluorescent molecules that light up when a neuron fires.And then there’s shape. Researchers first realized that neurons change shape by studying crayfish neurons more than 40 years ago. In 1977 a team of Stanford and UCSF researchers bounced a laser off a crayfish neuron as it fired and showed its width changed by roughly the thickness of a strand of human DNA.Yet translating those results into a way of optically observing neurons firing in human or other mammalian brains faced a number of challenges. For one thing, crayfish neurons are 10 to 100 times thicker than mammal neurons. For another, the technique that original group used – a simple form of what’s called interferometry – can only measure changes in a single point at a time, meaning it could be used to study only a small area of one cell at a time, rather than imaging the whole cell or even a network of neurons communicating with each other in the brain.Shining new light on neuron firingTo solve some of those problems, Ling, Palanker and colleagues first turned to a variation on standard interferometry called quantitative phase microscopy which allows researchers to map out entire microscopic landscapes – for example, the landscape of a network of cells arrayed on a glass plate. The technique is simple enough that it can be done by shining laser light through those cells, passing it through a few lenses, filters and other optical elements and filters, and recording the output with a camera. That image can then be processed to create a topographic map of the cells.Related StoriesNeural pathways explain the relationship between imagination and willingness to helpDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustResearch team to create new technology for tackling concussionLing, Palanker and the team reasoned they could use the technique to measure how much neurons change shape when they fire. To test the idea, they grew a network of neuron-like cells on a glass plate and used a video camera to record what happened when the cells – actually kidney-derived cells modified to behave more like neurons – fired. By syncing the video with electrical recordings and averaging over several thousand examples, the team created a template that describes how cells move when they fire: over about four milliseconds, cell thickness increases by about three nanometers, a change of roughly one-hundredth of 1 percent. Once it reaches maximum thickness, the cell takes about another tenth of a second to shrink back down.Watching brain cells at workIn the initial phase of the experiment, the team needed electrodes to figure out when the cells fired. In the second phase, the team members showed they could use their template to search for and identify cell firing without relying on electrodes.Still, there are a number of steps to take before the team can make the method work in real brains. First, the team will need to make the technique work in actual neurons, as opposed to the neuron-like cells they’ve looked at so far. “Neurons are more finicky,” Palanker said, but the team has already started experimenting with them.A second challenge is that neurons in real brains aren’t arranged in a single layer on a glass plate, as were the cells Palanker’s lab studied. In particular, the team can’t shine lasers through the brain and expect to see much of anything come out the other side, let alone useful data. Fortunately, Palanker said, the techniques they used with transmitted light work similarly in reflected light, and most neurons reflect enough light that the approach should in theory work.There is one limitation that the team probably won’t be able to get around – since light doesn’t penetrate deep into the brain, the new method will only be able to probe the outer layers. Still, for projects that only need to study these layers, the technique could give researchers a cleaner, simpler way to study the brain.”Usually, invasive methods affect what cells do, hence making the measurements less reliable,” Palanker said. “Here you do nothing to the cells. You basically just watch them move.”
Source:https://www.aftau.org/weblog-medicine–health?&storyid4704=2430&ncs4704=3 Reviewed by Alina Shrourou, B.Sc. (Editor)Jan 10 2019Our DNA is under constant attack. The delicate molecule that contains our genetic information is extremely vulnerable to everything from environmental agents, such as radiation, to the chemicals in the air we breathe and the food we eat. Genome instability can lead to genetic disorders, chronic diseases and a predisposition to cancer.A new Tel Aviv University study identifies elevated levels of a protein called ubiquilin-4 as a new biomarker for genome instability. The study finds that ubiquilin-4 takes part in defending the genome from DNA damage, but too much ubiquilin-4 is harmful. When the amount of ubiquilin-4 rises in tumor cells, the cells become more prone to genome instability, accelerating the tumor’s progression and making it resistant to commonly used cancer treatments.The study was led by Prof. Yossi Shiloh of the Department of Human Molecular Genetics and Biochemistry at TAU’s Sackler School of Medicine, in close collaboration with Prof. Christian Reinhardt of University Hospital Cologne and University of Cologne. Research for the study was carried out in Tel Aviv by Dr. Ron Jachimowicz, now at the University Hospital of Cologne, and Dr. Yael Ziv and PhD student Bhavana Velpula, both of TAU. Dr. Dave Hoon of the John Wayne Cancer Institute in Santa Monica, CA, also contributed to the research. It was published on January 3, 2019, in Cell.”This novel biomarker provides new, critical information about the tumor stage and grade, as well as the patient’s chances of responding to treatment,” says Prof. Shiloh. “Tumors with high levels of ubiquilin-4 may be more resistant to radiation and some chemotherapies than those with normal levels of this protein. But the good news is that they may also respond better to other types of cancer therapy. Obviously, this is vital information for clinicians and patients.”The importance of maintaining genome stability and integrity has been demonstrated through the study of rare genetic disorders,” Prof. Shiloh continues. “But genome stability has now become a public health issue. There are so many proteins involved in responding to DNA damage, and behind every protein is a different gene. There are infinite ways in which a gene can mutate. Various combinations of these mutations may lead to chronic diseases and a predisposition to cancer, premature aging and other conditions. Genome stability is everyone’s problem.”Related StoriesLiving with advanced breast cancerTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerResearchers use AI to develop early gastric cancer endoscopic diagnosis systemAccording to the new research, the body’s DNA damage response is key to maintaining genome stability in the face of the constant onslaught of damaging agents. The response is composed of a broad, fine-tuned signaling network involving a standing army of proteins fully dedicated to this mission, as well as reserve proteins recruited temporarily to help resolve genome integrity.In 1995, the Shiloh lab discovered the gene encoding of one of the major sentries at the gate of genome stability — the protein ataxia-telangiectasia mutated (ATM). The finding was met with great fanfare. It concluded a long effort to identify the gene mutated in a severe genome instability syndrome, ataxia-telangiectasia (A-T).But ATM also plays a critical role in the body’s DNA damage response, mobilizing an extensive signaling network in response to tears in the long DNA molecule. It causes subtle chemical modifications in many proteins, which temporarily render them reserve proteins and recruits them away from their regular duties to carry out damage control.”We are constantly searching for new reserve proteins that respond to ATM’s call,” Prof. Shiloh says. “Our new study shows that, like many other proteins, ubiquilin-4 is modified by ATM, and for several hours it serves the ATM-governed system.”The researchers, in collaboration with Prof. Dagmar Wieczorek of the Institute of Human Genetics at Heinrich-Heine-University in Düsseldorf, also discovered that the deficiency of ubiquilin-4 alone can lead to yet another rare genome instability syndrome.”We hope our findings will provide a new tool for tumor classification, prognosis and treatment design,” Prof. Shiloh concludes. “The research highlights the broader implications of the importance of genome stability for our health.”
Reviewed by James Ives, M.Psych. (Editor)May 17 2019Emergency room patients increasingly leave California hospitals against medical advice, and experts say crowded ERs are likely to blame.About 352,000 California ER visits in 2017 ended when patients left after seeing a doctor but before their medical care was complete. That’s up by 57%, or 128,000 incidents, from 2012, according to data from the Office of Statewide Health Planning and Development.Another 322,000 would-be patients left the emergency room without seeing a doctor, up from 315,000 such episodes in 2012.Several hospital administrators said overcrowding is a likely culprit for the trend. California emergency room trips grew by almost 20%, or 2.4 million, from 2012 to 2017.Moreover, ER wait times also increased for many during that time period: In 2017, the median ER wait time for patients before admission as inpatients to California hospitals was 336 minutes — or more than 5½ hours. That is up 15 minutes from 2012, according to the federal Centers for Medicare & Medicaid Services. The median wait time for those discharged without admission to the hospital dropped 12 minutes over that period, but still clocked in at more than 2½ hours in 2017.California wait times remain higher than the national average. In 2017, the median length of a stay in the ER before inpatient admission nationwide was 80 minutes shorter than the median stay in California. Four states — Maryland, New York, New Jersey and Delaware — had even longer median wait times.The growth in patients leaving California ERs prematurely was faster than the growth in overall ER encounters. About 2.4% of ER trips in 2017 ended with patients leaving the ER against medical advice or abruptly discontinuing care after seeing a doctor, compared with 1.8% in 2012.”Most patients are sick but not critically ill,” said Dr. Steven Polevoi, medical director of the emergency department at UCSF Helen Diller Medical Center at Parnassus Heights. “Emergency care doesn’t equal fast care all of the time.”When a patient leaves the ER after seeing a doctor but before the doctor clears them to leave, the Office of Statewide Health Planning and Development classifies that encounter as “leaving against medical advice or discontinued care.” The definition includes encounters in which a doctor carefully explains the risks to the patient and has the patient sign a form, but also instances in which the patient simply discontinues care and bolts out the door.Patients leaving the emergency room too soon “are deliberately putting themselves at more risk for morbidity and even mortality,” Polevoi said — a point echoed by other physicians.Dr. Veronica Vasquez-Montez, emergency room medical director at Good Samaritan Hospital in Los Angeles, said she sometimes finds herself having “tough conversations” with sick patients intent on leaving the ER, often citing pressing responsibilities.”If you die from this,” she tells them, “you are good to no one you are caring for.”One of her recent patients was at high risk for a major stroke but insisted he needed to leave the ER to take care of his pet.”Guess what he came back for? A major stroke,” said Vasquez-Montez, also a clinical assistant professor at the University of Southern California’s Keck School of Medicine.Related StoriesMedicare Advantage overbills taxpayers by billions a year as feds struggle to stop itIt is okay for women with lupus to get pregnant with proper care, says new studyRaw meat can act as reservoir for bacteria associated with hospital infectionsCompared with all ER patients, those leaving against medical advice were more likely to be men; people ages 20 to 39; and uninsured or on Medi-Cal, the government insurance program for the poor, state figures show. They were also more likely to complain primarily of non-specific symptoms such as chest pain or a cough.Fresno, Shasta, Yuba, Kern, San Bernardino and Tulare counties had the highest proportion of ER encounters in 2017 that ended with patients leaving against medical advice or abruptly discontinuing care. Each of those counties recorded more than 4% of ER patients leaving too soon, state figures show.From 2012 to 2017, the number of emergency room encounters in Fresno County increased by almost 95,000, or 37%. At Fresno’s Community Regional Medical Center, about 9% of ER encounters ended with a patient leaving too soon, more than three times the statewide rate.Community Regional Medical Center is one of the busiest hospitals in the state. It recently instituted a “Provider at Triage” program that puts caregivers in the lobby area with patients, said Dr. Jeffrey Thomas, the hospital’s chief medical and quality officer. The hospital’s internal data now show fewer than 2% of patients leaving against medical advice or abruptly discontinuing care.”When patients bring themselves into the ED, they are seen in about 5 minutes by a qualified registered nurse and, on average, are seen by a provider within 30 minutes of arrival,” Thomas said in a statement.When a sick patient is about to leave the emergency room, doctors should determine why he or she wants to go, make sure the patient is capable of making a sound decision, involve friends and family, explain the course of treatment and, if nothing works, arrange for speedy follow-up care, said Dr. Jay Brenner, emergency department medical director at Upstate University Hospital-Community Campus in New York and co-author of several studies about patients leaving against medical advice.”When someone requests to leave,” Brenner said, “it needs to be a priority that ranks just below a cardiac arrest.”Phillip Reese is a data reporting specialist and an assistant professor of journalism at California State University-Sacramento.This KHN story first published on California Healthline, a service of the California Health Care Foundation. This article was reprinted from khn.org with permission from the Henry J. Kaiser Family Foundation. Kaiser Health News, an editorially independent news service, is a program of the Kaiser Family Foundation, a nonpartisan health care policy research organization unaffiliated with Kaiser Permanente.
Reviewed by Kate Anderton, B.Sc. (Editor)Jul 3 2019Advances in the treatment of children and adolescents with cancer have led to substantial improvements in survival, with a 5-year survival rate of childhood cancer close to 80%.However, treatments such as chemotherapy and radiation can have long-term effects on bone health, potentially impacting on the attainment of peak bone mass, predisposing to premature onset of low bone mineral density, or causing other bone-related side-effects, such as impairment of bone quality or avascular necrosis of bone.A new publication by the International Osteoporosis Foundation (IOF) Cancer and Bone Working Group reviews the latest knowledge in this area of clinical research and provides succinct recommendations for essential long-term follow-up of bone health in childhood cancer survivors. The review ‘Bone health in childhood cancer: review of the literature and recommendations for the management of bone health in childhood cancer survivors’ aims to help clinicians define specific groups at higher risk of long-term bone complications, identify unrecognized long-term adverse effects, and ultimately improve patient care. It includes a concise diagnostic-therapeutic algorithm which outlines a clinical pathway to aid physicians in the long-term care of their patients.Professor Maria-Luisa Brandi, Head of the Bone Metabolic Diseases Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Italy, and lead author of the study, states: “In children and adolescents treated for cancer, the attainment of peak bone mass, which is a fundamental factor affecting bone mass in adulthood, can be negatively affected. Lower bone mineral density and microarchitectural deterioration can persist during adulthood, thereby increasing fracture risk. That is why the bone health of children and adolescents with a cancer history should be carefully monitored, and patients should be informed of possible late complications of their previous medical treatment.”Related StoriesEngineered stem cells offer new treatment for metastatic bone cancerUsing machine learning algorithm to accurately diagnose breast cancerCancer killing capability of lesser-known immune cells identifiedAs well as cancer treatments such as chemotherapy, radiotherapy and stem-cell transplantation, factors which contribute to bone mass impairment in childhood cancer survivors include an inadequate diet (especially calcium and vitamin D deficiency); prolonged treatments with glucocorticoids; hormone alterations involving growth hormone and/or gonadal hormones; reduced or absent physical activity, and inflammation and altered secretion of cytokines due to cancer cells.The review also points to areas where there are substantial knowledge gaps and identifies the need for further research to clarify whether improving bone health in childhood cancer survivors differs from the management of bone disorders in the general population.Professor René Rizzoli, Chair of the IOF Cancer and Bone Working Group, added: Cancer treatments in youth have a multifactorial impact on bone fragility and a core objective, both during treatment and once the patient is in remission or cured, is to reduce the impact on future adult bone health. This requires long-term follow up, involving effective transition from pediatric to adult care, as well as good communication between pediatric oncology and primary care. As clinicians we must work together to help to maintain and protect our young patients’ skeletal health.” Source:International Osteoporosis FoundationJournal reference:Brandi, M.L. et al. (2019) Bone health in childhood cancer: review of the literature and recommendations for the management of bone health in childhood cancer survivors. Annals of Oncology. doi.org/10.1093/annonc/mdz120.
“If you are exposed to chemicals that are metabolized by Cyp2b or inhibitors of Cyp2b, this might mean that you are not metabolizing something else in the body that is important,” William Baldwin, professor and graduate program coordinator in the College of Science’s department of biological sciences, explained. “In turn, maybe your likelihood of retaining white adipose tissue increases and therefore your likelihood of being obese increases,” he added.Related StoriesResearch team receives federal grant to study obesity in children with spina bifidaNovel program in England’s third largest city helps reduce childhood obesityLiver fat biomarker levels linked with metabolic health benefits of exercise, study findsOn the contrary, female mice that are Cyp2b-null didn’t manifest increased body weight or white adipose tissue. When the researchers checked the blood samples of the mice, they found increased leptin, cholesterol, and ketosis in male Cyp2b-null mice, compared to wildtype mice.Furthermore, the liver triglycerides in male Cyp2b-null mice were higher than their counterparts, hinting a role of Cyp2b in fatty acid metabolism, despite having the same diet. Worse, there was a suggestive result of fatty liver disease progression is present in normal diet-fed Cyp2b-null male rats like the one in high-fat diet fed wildtype counterpart. As a result, the researchers found the role of Cyp2b in lipid homeostasis.This means that the male Cyp2b-null mice had heightened fatty liver disease even with a normal diet.“Cyp2b must be signaling something and telling the fat to go someplace, indicating that Cyp2b has dual roles: metabolizing toxicants and chemicals in the environment and pharmaceuticals, but it is also involved in the metabolism of lipids and probably involved in signaling to tell us how to distribute fat,” Baldwin added.“Females did not show as demonstrative changes in liver health, and significantly fewer changes in gene expression, as well as gene expression associated with liver disease,” the researchers said in the study.“Overall our data indicate that the repression or inhibition of CYP2B may exacerbate metabolic disorders and cause obesity by perturbing fatty acid metabolism, especially in males,” they concluded.The study is part of a three-year, $362,000 grant the lead author, Baldwin, received from the National Institutes of Health.Obesity by the numbersIn 2016 alone, there were more than 1.9 billion adults in the world who are overweight. Of these people, more than 650 million had obesity. The global prevalence of obesity almost tripled from 1975 to 2016.In the United States, 93.3 million adults are obese in 2015 to 2016. Obesity may lead to various complications, some of which are life-threatening. These include type 2 diabetes, some types of cancer, heart disease, and stroke, among others.The rate of obesity is continuously increasing; hence, studies are focused on finding causative factors that can provide insight into obesity. Also, determining these causes may help in the formulation of treatments and preventive measures to curb the worldwide epidemic.What is a fatty liver disease?Nonalcoholic fatty liver disease (NAFLD) is a condition wherein excessive amounts of fat is stored in the liver. The fat buildup is not caused by alcohol intake, instead, it’s linked to being overweight or obese. Journal reference:Melissa M Heintz, Ramiya Kumar, Meredith M Rutledge, William S. Baldwin, Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis, The Journal of Nutritional Biochemistry, https://doi.org/10.1016/j.jnutbio.2019.05.004. (http://www.sciencedirect.com/science/article/pii/S0955286318312385) Clemson University graduate student Melissa Heintz and professor William Baldwin recently published their collaborative research in the Journal of Nutritional Biochemistry. Image Credit: Pete Martin / College of Science By Angela Betsaida B. Laguipo, BSNJul 11 2019A type of metabolic enzyme, which aids detoxification, has been linked to obesity and fatty liver disease, a new study found.A team of researchers at the Clemson University found that Cyp2b gene, which metabolizes endo and xenobiotics, may be linked to age-onset obesity and dyslipidemia, especially in males. The researchers conducted the study, which was published in the Journal of Biochemistry, to determine if the exposure to specific chemicals enhances obesity. Specifically, they wanted to identify the role of Cyp2b in unsaturated fatty acid metabolism, regardless of diet. Some chemicals could inhibit the gene, an event shown in the experiment with Cyp2b-null mice.The team used a laboratory mouse model to explore the role of Cyp2b gene in obesity. It’s an enzyme involved in metabolism, particularly the chemical detoxification in the body. The researchers treated wildtype and Cyp2b-bull mice with a normal or high-fat diet for 10 weeks.After, they determined the molecular and metabolic changes that happened. They found that the male high-fat-diet-fed Cy2pb-null mice weigh 15 percent more than the wildtype mice given a high-fat diet. The greater weight has been linked to an increase in white adipose tissue.There were many potential implications for human health.
Explore further The union says workers in Amazon’s San Fernando de Henares centre, where they prepare packages for clients in Spain and Europe, have not had a wage increase since 2016 Amazon hit by first strike in Germany Citation: Amazon workers in Spain plan first ever strike (2018, March 13) retrieved 18 July 2019 from https://phys.org/news/2018-03-amazon-workers-spain.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2018 AFP “We have announced a strike for the first time in Amazon Spain but it will only take place in the logistics centre of San Fernando de Henares, near Madrid, the biggest in Spain and the first created in the country” in 2012, said Ana Berceruelo of the CCOO union.The strike is planned for March 21 and 22.Berceruelo said the online retail giant wanted to increase salaries below the inflation rate, and reduce allowances for night work as well as pay for overtime.CCOO says the workers in the San Fernando de Henares centre, where they prepare packages for clients in Spain and Europe, have not had a wage increase since 2016.Berceruelo said 1,100 Amazon employees, and 900 people employed by temping companies, work on site.She said that the average salary was around 20,000 to 21,000 euros ($24,800 to $26,000) a year against 19,000 euros in the logistics sector.”We will continue to maintain direct dialogue with our associates and guarantee the best working conditions, a competitive pay package, a great work atmosphere and professional opportunities,” the company said in a statement.Amazon has grown from a humble beginning as an online bookseller to a colossus of the internet whose founder Jeff Bezos is now the world’s richest man. More than 1,000 Amazon workers in Spain are planning to go on strike next week against a planned drop in allowances and overtime, a first in the country, a union said Tuesday.
OnLive game streaming service to start in June Despite the promise of high-end PC gaming at the fraction of the price, services such as Nvidia’s GeForce Now and PlayStation Now haven’t caught fire. Worse yet, OnLive, the pioneer in the field, went kaput, casting doubt on the viability of the technology.Part of the reason is that all these services are closed systems. Players who buy into them are restricted to playing on certain devices. Shadow takes a different approach. Blade opens up its streaming service to virtually any device and lets players treat it like any standard PC. The big difference is that instead of running on local hardware, the service lets players run their games remotely off a Xeon processor with 12 GB of DDR4 Ram, an Nvidia graphics card that’s the equivalent of a GTX 1080 and 256 GB of hard drive space.With that power, they can run nearly any game at max settings. It can even run hardware intensive applications such as Adobe Photoshop. The Shadow service essentially turns nearly any computer into a $2,000 gaming rig. On smartphones and tablets, it uses the screen like a monitor and players can use a Bluetooth controller to make the game perform like something on a console.Shadow could run the full “Fortnite” without compromises on an iPhone before “Fortnite” widely came out as an app on the App store. What’s more important is that the service acts like a PC because it is a PC except that the system runs on a data center. This freedom lets players install Steam and run mods for games that they own on the service. They can add Battle.net and play “Overwatch” on a tablet.Another important element about Shadow is that Blade dedicates computing resources for every player. That means there shouldn’t be a drop off in clarity or performance and the service can only grow as far as its hardware. In France where the company launched, it limited the number of people who could initially access the service until they had enough computers.That means the only questions facing Shadow is lag and stability. The company says it has built an end-to-end system that’s streamlined so that it works with minimal input delay. It functions so well that professional “Street Fighter” player Olivier “Luffy” Hay uses the service. I can attest that the service works flawlessly from the limited time I used it, but there are reports that actual use is less than stellar.I played “Rise of the Tomb Raider” on max settings on a laptop and continued the game on phone a few minutes later. Shadow started the game where I left off and the screen in both cases looked impressive without many noticeable artifacting. In fact, I did another test where I had two identical laptops next to each other, and I couldn’t tell the difference until one ran Adobe Photoshop faster than the other. (The faster one was using Shadow.)The service has plenty of potential and could be a reasonable alternative to a gaming rig. Players don’t have to worry about upgrading it. They can run nearly any peripheral, application or game. The only thing that gives me pause is the size of the hard drive. At 256 GB of storage, that’s not a lot for players with massive game collections. At this point, Blade says it has no plans to let players upgrade their 256GB of space so they’ll have to delete games on the service to make room for more.The service costs $35 per month with a locked-in annual subscription. It is costlier if players pay for it each month or in three-month segments. At the moment, Shadow is only available in California and select areas of Europe. ©2018 The Mercury News (San Jose, Calif.) Distributed by Tribune Content Agency, LLC. Citation: Preview: Shadow streaming service may succeed where OnLive, others failed (2018, April 20) retrieved 18 July 2019 from https://phys.org/news/2018-04-preview-shadow-streaming-onlive.html Explore further The biggest obstacle for Blade’s Shadow service is the past. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.