ST. LOUIS — Once the Oakland A’s started playing National League baseball Tuesday night, they beat one of the league’s best — historically and this season — at its own game.A double-switch by manager Bob Melvin in the bottom of the fourth inning set the stage for fireworks — back-to-back home runs and then a two-run double, by pinch hitting slugger Khris Davis — in the top of the fifth en route to a 7-3 victory over the St. Louis Cardinals in the interleague game at Busch Stadium.Oakland …
There’s an old legend that Tibetan monks built a wall by levitating heavy stones with sound by beating their drums and gongs. Something not quite so fantastic but still amazing is done by cells in the embryo. Scientists have filmed zebrafish embryos using beating cilia to build little stone structures that they use for balance. Animals need to know which way is up. All vertebrates have pieces of rock in their heads for this purpose (see 10/10/2003). These rocks made of calcium carbonate, called otoliths in fish and otoconia in humans, are tied to sensory organs that measure their inertia to determine balance, direction and motion. They are interesting examples of biomineralization – the use of mineral construction materials instead of proteins, sugars, fats and nucleic acids. Because minerals are hard things, they need to be guided into place like building blocks. How does a little fish embryo place the building blocks for otoliths that will work? “Otolith number, size and placement are under strict developmental control,” wrote a team of UCLA and Caltech scientists in Nature.1 Until now it was unknown how the embryo guided the building blocks into place. The team used high-speed digital video cameras on a microscope to film the growth of otic vesicles, the organs where otoliths form. At 100 to 330 frames per second, they observed that cilia attracted precursor particles by beating back and forth, creating little vortices in the fluid. At polar ends of the otic vesicles, longer cilia called “tether cilia” beat this way and attracted particles to their tips. The beating not only set up a fluid dynamic system that pulled the particles in, it also kept the growing structure rotating for even construction. They called this a “cilium-dependent hydrodynamic system.” The cilium uses dynein for motion and is dependent on a gene called Gas8 for regulation. Here’s the jargon:Our results demonstrate that Gas8 is required for normal motility of cilia in the otic vesicle and that ciliary motility is essential for normal ear development. The otic vesicle is a closed epithelial organ and fluid flow within this vesicle has been suggested to contribute to otolith formation. Our study provides direct experimental evidence in support of this hypothesis. On the basis of high-speed video microscopy of cilia motility and quantitative analysis of precursor particle movements in wild-type and gas8 morphant embryos, we propose a new, cilium-dependent hydrodynamic mechanism for otolith biogenesis (Fig. 4). In this model, motility of tether cilia at the poles of the otic vesicle establishes a vortex that attracts otolith precursors (Fig. 4i, l), thereby biasing an otherwise random distribution of precursor particles and concentrating them near the two patches of tether cilia. This ensures preferential otolith seeding at the poles of the otic vesicle. At the otic vesicle poles, tether cilia motility further serves to disperse precursor particles locally and oscillation of the otolith increases effective contact area with precursors (Fig. 4j). Together, this prevents particles from sedimenting to form ectopic aggregates and promotes efficient uniform otolith growth.Cool. The little fish embryo uses this organ to keep itself right-side up as it swims away. Although the scientists observed this phenomenon in fish, they believe the mechanism may have more general application. “Our findings add to a growing list of developmental processes requiring fluid dynamic inputs for proper growth and patterning, further showing that epigenetic cues are part of the embryonic developmental program.” They encouraged other biologists to look for answers to hearing loss and balance problems in humans in “ciliopathies” – diseases of the cilia. The Supplementary Information page contains Quicktime movies where you can see the beating tether cilia with otoliths growing at their tips.2 1. Colantonio et al, “The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear,” Nature 457, 205-209 (8 January 2009) | doi:10.1038/nature07520.2. Supplementary Information page for Colantonio et al, Nature.Think how many systems must interact in this amazing process. Cilia are among the “irreducibly complex” organelles Michael Behe described in detail in Darwin’s Black Box and The Edge of Evolution. All the parts of the cilia must be coded in the DNA – along with the assembly instructions for the cilia and the molecular trucks that build them (visit 06/14/2004 to be blown away by that fact). The cilia have to find their ways to the poles of the otic vesicle. They have to know how fast to beat to set up the proper vortex that will attract precursor particles. They have to start and stop beating at the right time and somehow “know” when the otoliths are the right size and shape. The sensory apparatus has to know what to do with the information provided by the inertia of the otoliths. The brain has to process this information and send course corrections to the muscles. A multitude of ancillary proteins, hormones and regulatory factors are involved. This is just for one sense organ in a tiny fish embryo. Did the fish figure this all out by trial and error? Remember – vertebrate fish have been found near the base of the Cambrian (01/30/2003), with all their systems appearing fully formed. OK, time for the quiz: did this paper mention evolution? For a change, YES! But you’ll get a bang out of their one lonely reference: “Cilia are evolutionarily conserved organelles that perform motility, sensory and transport functions and are required for normal vertebrate development and physiology.” Ha! You may now laugh your way to the Bank of I.D. and deposit this paper in a C.D. (Certificate of Design), where it will yield high interest, guaranteed.(Visited 36 times, 1 visits today)FacebookTwitterPinterestSave分享0
Guide to Performing Bulk Email Verification A Comprehensive Guide to a Content Audit sarah perez Related Posts The Dos and Don’ts of Brand Awareness Videos Tags:#mobile#twitter#web Beginning Tuesday night, BlackBerry maker RIM began rolling out its official “Twitter for BlackBerry” mobile application to users by way of the BlackBerry App World site, where it can be found under the “social networking” category.The app, which has been in beta since April, supports all the features one would expect from a mobile Twitter application, including access to timelines, replies, messages, trends and profiles. But it also includes several BlackBerry-specific options, including push notifications, hotkeys and integration with core BlackBerry apps.BlackBerry: Still Going StrongAlthough current news coverage may have you thinking otherwise, RIM’s BlackBerry line of smartphones is still popular, both among business users and consumers. The numbers for BlackBerry mobile Web usage, however, vary widely, with Quantcast reporting a 10%-plus share in North America (Mobile Web consumption, May, 2010),AdMob stating it’s 7% in North America (OS Share, May, 2010) and Percent Mobile claiming it’s a hefty 22% (Mobile Web consumption, May, 2010).For what it’s worth, though, the hard numbers based on units shipped saw RIM recently moving into the top-five vendor rankings for smartphones worldwide, ousting Motorola in the process – a change that proves there’s life in the ol’ BlackBerry platform yet. In fact, RIM was the only vendor in the top five with a singular focus on smartphones.Twitter for BlackBerry – the “Official Version” There were already several BlackBerry Twitter applications available, but none with the benefit of being dubbed the “official” app.But unlike the “Twitter for iPhone” app, the BlackBerry variation wasn’t released by the microblogging platform maker itself, but rather RIM (in an effort to remain relevant to the “app” obsessed?)The full list of features rival those found in any third-party creation and include the following:Push Notifications for Direct MessagesTimeline SupportFollowing and FollowersPosting, Sending, Deleting, Replying and Retweeting TweetsUser/Saved/Keyword/Proximity SearchTweet Photos/LinksTrending TopicsSeamless integration into core BlackBerry applicationsURL ShorteningAuto-UpdateQuote Tweets (editing retweets)Auto Complete for @ usernamesView Photos from Yfrog and TweetphotoView Geotagged TweetsPersonal Info GuardHotkeys for NavigationReport as SpamSupport for Dutch, Indonesian, Japanese, Korean, Portuguese (European), Russian and Turkish languagesDespite its “social networking” capabilities, Twitter is an important tool for many business users who need to stay on top of breaking news and other relevant information, making it a good fit for BlackBerry and its push notification system.According to the AppWorld site, the app works on all devices from all carriers, in all countries except China. Facebook is Becoming Less Personal and More Pro…
RedMonk’s Stephen O’Grady challenges the conventional wisdom that Java is dying – a position typified by recent comments from Forrester analysts. O’Grady acknowledges that although Java has peaked in terms of popularity, it is hardly the dead end that Forrester claims it is.O’Grady bases his claims on various data collected by RedMonk. RedMonk’s research is focused on developers, instead of enterprise “decision makers.” “We advantage this audience simply because we believe that bottom up adoption is more predictive of technology direction than top down procurement, but reasonable minds may obviously disagree,” O’Grady writes.This diagram illustrates the thinking behind RedMonk’s focus on developers: Tags:#enterprise#Trends Related Posts 3 Areas of Your Business that Need Tech Now Cognitive Automation is the Immediate Future of… Massive Non-Desk Workforce is an Opportunity fo… Yakov Fain, author of several books on Java, agrees. “Unfortunately, people who state that Java’s dead are not the people who use the latest Java technologies day in and day out,” Fain writes.O’Grady believes that Java use is declingng not because it is dying, but because there are so many specific use tools available now. O’Grady has written about this explosion of growth of specialized tools before. Although NoSQL databases provide an alternative to relational databases, it doesn’t mean that relational databases will go away. Likewise, Node.js provides a specialized alternative to Apache, but won’t kill Apache. So it goes with Java. From Clojure to Ruby to Node.js, there are many alternatives to Java. But Interest in Java is still high. O’Grady presents various data to make the case, including this analsysis of the comments on Hacker News: O’Grady also notes how important Java is to platforms like Hadoop, HBase and Cassandra. “Even as the rapid expansion of the Hadoop ecosystem permits the usage of more accessible languages like Python (Dumbo) and Ruby (Wukong), Java is the foundation upon which the entire edifice rests.” One might also mention Scala’s use of the JVM in this context, and the use of Java on Android devices.What we’re witnessing is not the death of Java, but its transformation. It’s moving from being just a general use platform that dominated the enterprise to being the guts of many disparate technologies for various special applications. klint finley IT + Project Management: A Love Affair
As I’ve said before, windows are a silent but very high-tech part of our buildings. The advances in glazing in the last 30 years have been phenomenal. Will windows keep getting better and better with no end in sight?In recent years, an increasing number of window manufacturers have been combining and refining the features that have given us today’s high-performance windows: multiple layers of glazing, multiple low-emissivity (low-e) coatings, and very-low-conductivity gases such as krypton. They’ve been creating super-high-performance windows, or “superwindows,” a term coined by Dariush Arasteh, a staff scientist at Lawrence Berkeley National Laboratory. In the early 1990s, Arasteh predicted that advances in technology could make all windows, even north-facing windows in northern climates, net-energy-gainers. Whether or not that day has arrived is a matter of debate, but there’s no doubt that the advances since the 1990s, when window buyers were dreaming of U-0.05 (R-20) windows (and window makers were making tantalizing demonstrations in that direction), have been astounding.The superwindow race cools off…Today, that race has cooled off to some extent in favor of climate-specific solutions. As Stephen Thwaites of Thermotech Fiberglass in Canada told me, “A window doesn’t have to be R-20 to be as energy-efficient as the wall around it,” due to the ability of a window to gain solar heat and provide ventilation. “A home with no windows will use more energy than a properly designed home with R-5 windows,” Thwaites said.That’s a change from the mid-1990s when the prototype quintuple-glazed window shown above was built by Thermotech as a demonstration of what was possible, with a goal of R-20. Today, ambitions have become more climate-specific.… But it’s still exciting to look for what’s nextToday, R-5 windows are aspirational for many, but not really that special in the windows market. But instead of pushing past that, we are seeing more emphasis on proper design by orientation, shading, and window-to-wall ratios, and on buying the best windows for each application according to the budget.It’s still exciting to dream of what we’ll see in the next 30 years. For example, vacuum glazing, in which most of the air is evacuated from the space between panes, reduces thermal conduction and convection to nearly zero (leaving radiation as the primary means of heat transfer), and can currently offer U-0.08 (R-12) with double-glazing and one advanced low-e coating. Vacuum glazing is still largely in research and development, however. The seal is tough to get right, since the vacuum puts a lot of pressure on it.The biggest limit on energy performance is and may continue to be not what technology can do, but what the buyer can afford. Windows imported from Germany meeting the Passivhaus standard, for example, offer U-factors under 0.14 — at a cost of over $90 per square foot of window area. Triple-glazed Canadian windows typically cost $40–$50 per square foot, in contrast with a price range for more conventional double-glazed windows of $30–$35.The problem with getting great windows is how they’re soldOn the subject of price, I’m going to quote a few paragraphs here from a comment I received by email after last week’s post about reading NRFC labels. This comment with some follow-up discussion is posted on last week’s column.“Your recent columns on windows have struck a raw nerve, and it’s worth sharing why. Construction has just begun on a small sunroom addition to my home. The problem with getting great windows is not product availability, but the awkward way they are sold.“Building supply dealers seldom post prices of anything. Items which are ordered, like windows that have lots of options and sizes, are much worse — requiring the entry of data into a computer to get a quote. The quote of course is for the whole window, making it really tedious to test out individual options. The retail staff, though both knowledgeable and helpful, cannot possibly keep prices for all those options in their heads, and nothing good can come from a customer mistaking a ballpark guess for a quote.“Net result: it is ridiculously difficult to get a cost comparison of option A vs. option B, on anything. In my case of a south-facing sunroom where I knew I’d be starting a lot of veggie seedlings in spring, I depended on my own reading and research in preferring clear glass (full-spectrum, high solar gain), and triple pane (reduced heat loss). It took several days to get a price.“Going through that process for the dozens of decisions in a given project is simply not going to happen. Even a highly motivated customer has little choice but to just give up and trust the contractor to do something reasonable. And still miss here and there. You recently noted that using argon gas was a no-brainer; that column came too late, and I didn’t expend the effort to price argon vs. air.”It may not help to say this, but if you’ve faced this window-pricing issue, you’re not the only one. Martin Holladay had some great comments on this two weeks ago which I’ll paraphrase here. There is little transparency on pricing in the window industry, and someone who wants to really shop around and price out different options easily faces dozens of hours of research on a new home. Hopefully they can get good cooperation from dealers, but that’s not always a given. It would be great to see just one window manufacturer post accurate and complete prices online. I suspect it would make their business stronger, not weaker.Tristan Roberts is Editorial Director at BuildingGreen, Inc., in Brattleboro, Vermont.
What do you think of this stunt? The numbers seem to indicate that it was effective. Don’t forget to share this post! AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to Email AppEmail AppShare to LinkedInLinkedInShare to MessengerMessengerShare to SlackSlack sent an icy message to payment giant, PayPal at its annual development conference in San Francisco. PayPal, a WePay competitor, has had negative publicity in the past around the issue of WePay • Conversions on the stunt landing page were 3x higher than a normal day. • 300% increase in weekly traffic • 225% increase in signups According to the WePay team, yes it did. The folks at WePay shared the following results with us from the days following the stunt: Takeaways From a Successful Marketing Stunt Those are pretty dramatic results. How did they do it? At 7:45 a.m. on Tuesday morning, the group payment startup With a limited budget, competing against a giant in the payment industry, WePay elected to do a marketing stunt to get its message across. The WePay team wheeled a massive block of ice with frozen money and a message to PayPal customers and developers: “PayPal Freezes Your Accounts.” One minute after dropping off the massive block of ice in front of San Francisco’s Moscone Center, WePay employees were confronted by security. An hour and half later, the stunt was on the front page of TechCrunch , one of the most popular technology news sites on the web today. freezing some of its members’ accounts 2. Be Ready to Make a First Impression- The WePay team had prepared for a spike in engagement. They were ready for more emails, calls, and tweets than normal. With lots of new potential users talking about the stunt, the team needed to be ready to respond and make sure it created a good first impression. Originally published Oct 29, 2010 9:20:00 AM, updated March 21 2013 3. Have Fun With the Stunt- When you create something interesting, people always want to know how you did it. It is important to understand that the stunt is meant to be fun, and while you are putting it together, you should plan to take pictures to share with your community. For example, the folks at WePay documented the process on their blog. More Than a Cute Story?Sure, that sounds like a fun story, and I am sure the folks at WePay had a lot of fun doing it, but did it drive actual business results? 1. Have a Dedicated Landing Page- WePay had a dedicated landing page for its stunt: UnfreezeYourMoney.com. On this page, WePay had two separate calls-to-action for its buyer personas: new users and developers. This landing page converted at a 10% higher rate than the company’s homepage. . WePay obviously wanted to let PayPal customers and developers know that they would not experience the account freeze issue if they were using the WePay system.
We all make mistakes when we’re learning something new. That philosophy stands true for business people and school children alike. So what separates those who learn and succeed from those who learn and fail? Why, it’s the correction of one’s mistakes and seeking improvement, of course! Social Media Strategy integrating social media I won’t call anyone out specifically, but unfortunately, I see this a lot. (And I mean, a lot.) I applaud businesses that take the first big leap in How to Screw Up Your Social Media Strategy “I’m not getting social media results right now, so clearly it’s useless.” Whoa, there! Did you even give it a solid chance? When you go to a networking event, do you expect to develop strong business relationships with all 50 attendees that very evening? I imagine you understand it will take multiple weeks, perhaps months of meetups before you develop solid relationships with every person. Similarly, it takes lots of commitment and nurturing to develop a successful community through any social network, too. creating a Facebook Page Only marketing people can successfully represent your company, right? Wrong! By allowing all employees to tweet company content, discuss what they’re working on, or announce special news, your business’ reach just tripled… quadrupled. (You count your employees and do the math.) That’s very valuable, especially when you’re all-hands-on-deck regarding a specific announcement. ” 1. Set up your profile, and ignore it forever. 6. Give up after three weeks. At HubSpot, our social media policy is pretty simple: “Use Common Sense.” And we encourage others to adopt that same attitude. When you’re interacting through social media channels, the name of the game is fast and nimble. Unless you have a person dedicated to reviewing social media content who also has the response time of a tennis player, you’re shooting yourself in the foot. Create a list of the type of content you want published, and trust your employees from there. You’ll be glad you did. 4. Have management review all social media posts and responses before publishing. So what do you think? Are you guilty of making any of these mistakes? How have you improved? What other social media mistakes should businesses avoid? What do you think?
Originally published Sep 26, 2011 3:00:00 PM, updated October 20 2016 Don’t forget to share this post! AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to Email AppEmail AppShare to LinkedInLinkedInShare to MessengerMessengerShare to SlackSlack Topics: Running out of ideas for your blog? Think about incorporating data in new ways. When leveraged well, data can breathe life and new significance into your posts. This doesn’t mean threading spreadsheets directly into your posts. Rather, you should think about how to responsibly frame the data in a way that will advance your narrative. U.S. Statistician and Sculptor Edward Tufte once called this “escaping the flatland.”By putting data into context and using it to strengthen your point, you can give readers a post that will stay with them long after they’ve left the page. Here are a few narrative techniques to think about when using data in your posts.1. Demonstrate ChangeThere is no more powerful narrative technique than using data to demonstrate change over time. In the example below, Latoya Egwuekwe uses data and maps to demonstrate the changing “Geography of a Recession” over time. The darker colors in the geographic representation indicate higher unemployment rates. As you watch the video, you can see the map growing darker over time.Lesson: Showing a striking trend of change (whether it be deterioration or dramatic improvement) not only brings weight to the discussion, but it can also evoke an emotional response from your blog readers/viewers. 2. Show DiscrepancyIsolated on its own, data can fall flat. But put a set of data into context to highlight discrepancies, and you have a strong narrative. In the example below, The New York Times highlights the discrepancy between the national budget forecasts since 1982, and the reality.The Washington Post has another great example, placing the number of jobs available next to the number of new hires and highlighting a growing skills gap in America. By showing discrepancies between perception and reality or between two sets of data, you can highlight gaps that lead to clear calls-to-action. Our own Dan Zarrella has adopted this technique in his own research by showing the difference between the perception of when emails should be sent during the week vs. the reality of when effective sends take place. 3. Show Connection or CorrelationIn this map, the Community Farm Alliance used data to demonstrate that neighborhoods without easy access to grocery stores in Louisville are also those with higher densities of fast food. The implied connection suggests that these communities have disproportionately limited access to healthy foods. Note: When showing the correlation between two things, be careful that you don’t imply causation. Be clear that you’re only showing that two things are connected in some way; not that one is directly leading to the other. 4. Give ScaleFinally, think about using data to demonstrate scale. In this chart, The Economist uses a visual representation of data to demonstrate the scale of each of the top ten employers globally.Again, scale can help you add context to your posts. What data do you have that can lend itself to this type of visualization? Did you serve more customers last year than the average number of attendees at a Red Sox game? How can you show the scope of your impact?Hopefully these four techniques help you to think about data in a new way. What ways have you used data to underscore a point in a blog post? Are there any effective examples you can share? Data Visualization