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Boost for US retailers as strong holiday sales offer hope for American recovery

first_imgTuesday 14 December 2010 9:05 pm whatsapp Share whatsapp KCS-content THE Fed’s second phase of quantitative easing (QE2) came under attack yesterday, after jumps in retail sales, business morale and inflation.Retail sales for November increased by 0.8 per cent, and figures for the previous month were revised upwards to show a 1.7 per cent rise.“Today’s figures suggest that QE2, announced on 3 November, is totally superfluous, as well as being largely ineffective – except for pushing up stock prices,” said Rob Carnell, chief economist at ING.“Underlying sales growth [excluding petrol price hikes] has been ticking along at this decent rate for four months,” said Capital Economics.And the National Federation of Independent Business (NFIB) announced a rise in optimism to its highest level for three years.Despite the rise, business optimism is still at recession levels, Bill Dunkelberg of NFIB warned.Core producer prices (excluding oil and food) jumped 0.3 per cent in November, against the previous month.“Whilst not inflationary, the high figures suggest that the Fed’s concerns over deflation are substantially overdone,” said Carnell. Last week Fed chairman Ben Bernanke hinted at a third period of easing (QE3), citing concerns over growth and unemployment. “That really does not look credible right now,” commented Carnell. Show Comments ▼ Boost for US retailers as strong holiday sales offer hope for American recovery More From Our Partners Florida woman allegedly crashes children’s birthday party, rapes teennypost.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgI blew off Adam Sandler 22 years ago — and it’s my biggest regretnypost.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comBrave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgSupermodel Anne Vyalitsyna claims income drop, pushes for child Tags: NULLlast_img read more

Government seals deal over bank lending and bonuses

first_img More From Our Partners Brave 7-Year-old Boy Swims an Hour to Rescue His Dad and Little Sistergoodnewsnetwork.orgRussell Wilson, AOC among many voicing support for Naomi Osakacbsnews.comA ProPublica investigation has caused outrage in the U.S. this weekvaluewalk.comNative American Tribe Gets Back Sacred Island Taken 160 Years Agogoodnewsnetwork.orgKiller drone ‘hunted down a human target’ without being told tonypost.comPolice Capture Elusive Tiger Poacher After 20 Years of Pursuing the Huntergoodnewsnetwork.orgSupermodel Anne Vyalitsyna claims income drop, pushes for child supportnypost.comAstounding Fossil Discovery in California After Man Looks Closelygoodnewsnetwork.orgInside Ashton Kutcher and Mila Kunis’ not-so-average farmhouse‘Neighbor from hell’ faces new charges after scaring off home buyersnypost.comMark Eaton, former NBA All-Star, dead at 64nypost.comMatt Gaetz swindled by ‘malicious actors’ in $155K boat sale boondogglenypost.comBiden received funds from top Russia lobbyist before Nord Stream 2‘The Love Boat’ captain Gavin MacLeod dies at 90nypost.comFlorida woman allegedly crashes children’s birthday party, rapes teennypost.comI blew off Adam Sandler 22 years ago — and it’s my biggest regretnypost.com980-foot skyscraper sways in China, prompting panic and evacuationsnypost.comUK teen died on school trip after teachers allegedly refused her The government has reached an agreement with the largest UK banks on lending and bonuses.Under Project Merlin, banks will lend about £190bn to businesses this year.Of that £76bn will go to small firms, starved of lending.The Bank of England will assess whether the loans targets are met met.Chancellor George Osborne formally ruled out imposing a bonus tax.But the chairmen of banks’ remuneration committees say are cutting the amount provided for bonuses in 2010, after negotiations with ministers. HSBC, Barclays, Royal Bank of Scotland (RBS) and Lloyds Banking Group have signed up to Project Merlin, while Santander has agreed to the lending parts of the agreement.Santander UK chief executive Ana Botín said: “We are fully behind the government’s growth agenda and focus on supporting SMEs. Santander will continue to increase its lending to SMEs and its market share, as it has done for the past two years.”Bob Diamond, chief executive of Barclays, said: “The UK has been our home for 320 years, and we are committed to play our part in enabling and supporting the recovery of the British economy. The plans set out in this announcement demonstrate our commitment to doing that.” Lloyds Banking Group said in a statement that it was reducing its chief executive Eric Daniels’ bonus to £1.45m. “The Board took into account the current environment and desire for restraint. It is proposed that this award will be deferred into shares until at least March 2013, which exceeds FSA requirements,” it said.Other pledges include providing £200bn of capital for David Cameron’s Big Society Bank, which is supposed to finance community projects.Banks have also been urged to rein in bonus payments. Show Comments ▼ whatsapp Wednesday 9 February 2011 7:03 am Government seals deal over bank lending and bonuses center_img by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeMisterStoryWoman Files For Divorce After Seeing This Photo – Can You See Why?MisterStoryUndoTotal PastThe Ingenious Reason There Are No Mosquitoes At Disney WorldTotal PastUndoSerendipity TimesInside Coco Chanel’s Eerily Abandoned Mansion Frozen In TimeSerendipity TimesUndoZen HeraldNASA’s Voyager 2 Has Entered Deep Space – And It Brought Scientists To Their KneesZen HeraldUndoBrake For ItThe Most Worthless Cars Ever MadeBrake For ItUndoBetterBe20 Stunning Female AthletesBetterBeUndoAlphaCute30 Rules That All “Hells Angels” Have To FollowAlphaCuteUndoDefinitionDesi Arnaz Kept This Hidden Throughout The Filming of ‘I Love Lucy’DefinitionUndoTaonga: The Island FarmThe Most Relaxing Farm Game of 2021. No InstallTaonga: The Island FarmUndo Share John Dunne Tags: NULL whatsapplast_img read more

Sports bar chain set to make sports betting move

first_img US sports bar and restaurant chain Buffalo Wild Wings has confirmed to it is looking to offer sports betting.The chain – also known as B-Dubs – has not offered a timeline on the proposed change, which could shake up the sports betting sector in the US by providing significant cut-through to the public.“As the largest sports bar in America, we believe Buffalo Wild Wings is uniquely positioned to leverage sports gaming to enhance the restaurant experience for our guests,” a company spokesperson told“We are actively exploring opportunities, including potential partners, as we evaluate the next steps for our brand.”The chain did not elaborate to whether those partners would be casinos or other sports betting providers, such as daily fantasy sports operators.With a presence in every US state and more than 44,000 employees, the introduction of sports betting would establish B-Dubs a significant presence, cutting across the country – pending legislative approval in various states, of course.It is anticipated that at least 15 US states will have passed laws to regulate sports betting by the end of next year, with at least 32 states estimated to have approved legislation within five years.B-Dubs, which has suffered a slowdown in sales in recent years, was recently acquired by Roark Capital Group for $2.9bn. Following the takeover, CEO Paul Brown told Business Insider that B-Dubs’ competition had “been a little bit more innovative”.The chain has a track record of pushing promotions around major sports events, such as the ‘March Madness’ college basketball extravaganza and the NFL Draft.However, B-Dubs’ move into allowing gambling would raise numerous questions, not least whether B-Dubs would be able to introduce sports betting at all of its locations, or only those it operates directly.Around half of the chain’s 1,238 outlets are directly owned, with the remainder being franchised. Sports bar chain set to make sports betting move Topics: Sports betting Tech & innovation Email Address Buffalo Wild Wings, which has a presence in every US state, seeks partners 10th August 2018 | By contenteditorcenter_img Sports betting Regions: US AddThis Sharing ButtonsShare to LinkedInLinkedInShare to FacebookFacebookShare to TwitterTwitter Subscribe to the iGaming newsletterlast_img read more

Demings announces security grants for Central Florida

first_img Free webinar for job seekers on best interview answers, hosted by Goodwill June 11 Support conservation and fish with NEW Florida specialty license plate LEAVE A REPLY Cancel reply The Anatomy of Fear You have entered an incorrect email address! Please enter your email address here Please enter your comment! Share on Facebook Tweet on Twitter TAGSMedicareRep. Val Demings Previous articleChildren dying in hot cars: a tragedy that can be preventedNext articleWhat’s New to Streaming in August? Denise Connell RELATED ARTICLESMORE FROM AUTHOR Please enter your name here From US Representative Val DemingsRep. Val Demings announced new federal anti-terror grants approved for Central Florida.  These grants follow Orlando’s inclusion in the Urban Area Security Initiative (UASI) program for the second year in a row, announced in April.The first grant totals just over $1 million for Port Canaveral under the Port Security Grant Program.  The second awards $290,000 to the Chabad Lubavitch of North Orlando, the Jack and Lee Rosen Jewish Community Center, and Temple Israel to provide security assessments, enhancements, and training for the nonprofit institutions.The grants awarded to Central Florida increased with UASI more than doubling to $3.25 million and the Nonprofit Security grant growing from $225,000.Said Rep. Demings, “I am grateful that Central Florida is receiving the funding we need to ensure that our communities remain safe places to live, work, worship, and visit.  Security is our top priority, and with these grants, the federal government is doing its part to help ensure we remain ahead of those seeking to do harm.”BackgroundThe Urban Area Security Initiative (UASI) provides funding to help with anti-terrorism planning, organization, equipment, training, and exercises in urban areas which could be targeted.Orlando received $1.5 million in UASI funding in 2018 after a 4-year lapse.  As Orlando’s former Chief of Police, Rep. Demings previously oversaw the use of UASI funding by OPD. Since her election in 2016, Rep. Demings has prioritized restoring anti-terror and preparedness funding for Central Florida.Orlando’s competitive Nonprofit Security Grant funding is provided to jurisdictions that are awarded UASI funding. Save my name, email, and website in this browser for the next time I comment.last_img read more

Home for Life / AART Architects

first_imgArchDaily Projects ShareFacebookTwitterPinterestWhatsappMailOr Clipboard CopyHouses•Lystrup, Denmark Products used in this ProjectTilesCupa PizarrasNatural Slate CUPA 98Engineer:Esbensen Consulting EngineersDeveloper:VKR HoldingBuilder:Velfac and VeluxCity:LystrupCountry:DenmarkMore SpecsLess SpecsSave this picture!Courtesy of AART ArchitectsText description provided by the architects. With buildings accounting for 40% of carbon emissions in the Western world, and 30% of buildings having deficient indoor climates, we sought to create a carbon-neutral building that would benefit from solar energy, both actively by producing electricity and solar heat and passively by benefitting from the heat of the sun.Save this picture!Courtesy of AART ArchitectsSave this picture!SituationSave this picture!Courtesy of AART ArchitectsTogether with engineers, manufacturers and researhers, we came up with the design for Home for Life – an active house producing more energy than it consumes. With an expected energy surplus of 9 kWh/m2/year, it takes Home for Life approximately 35 years to produce the same amount of energy that was used to produce its materials, and by that time, the house will have returned more to nature than it has consumed. Over the long-term, therefore, the house will be an asset for rather than a burden on the environment.Save this picture!Courtesy of AART ArchitectsSave this picture!Ground floor planSave this picture!Courtesy of AART ArchitectsFurthermore, the structure of Home for Life is made of wood, while the facades are clad with natural slate, the floor tiles consist of mosaics of recycled glass and the windows use the latest energy-conserving glass technology. In addition, the window area represents 40 percent of the surface area, which is twice the area compared to a traditional single-family house.Save this picture!Courtesy of AART ArchitectsSave this picture!First floor planSave this picture!Courtesy of AART ArchitectsIn this way, Home for Life ensures a healthy indoor climate by optimizing daylight, creating a close contact with nature and having integrated sensors that measure the heat, air humidity and CO2 in all rooms. The house also has an automatic facade system that adapts to the seasons of the year and draws fresh air into the house.Project gallerySee allShow lessT2.a Architects Uses Algorithm to Design Customizable Apartment ComplexArchitecture News“Les Fuseaux“ Cultural Center / ANMASelected Projects Share Home for Life / AART Architects ShareFacebookTwitterPinterestWhatsappMailOr Clipboard CopyAbout this officeAART ArchitectsOfficeFollowProductsWoodBrick#TagsProjectsBuilt ProjectsSelected ProjectsResidential ArchitectureHousesLystrupDenmarkPublished on March 30, 2018Cite: “Home for Life / AART Architects” 30 Mar 2018. ArchDaily. Accessed 11 Jun 2021. ISSN 0719-8884Browse the CatalogPartitionsSkyfoldVertically Folding Operable Walls – Zenith® SeriesVinyl Walls3MExterior Vinyl Finish – DI-NOC™ StoneShowerhansgroheShowers – Croma SelectDoorsRaynorGarage Door – Advantage SeriesConcreteSika3D Concrete PrintingSignage / Display SystemsGoppionDisplay Case – Bre-ClassSkylightsVELUX CommercialModular Skylights in Atelier Zimmerlistrasse OfficeWindowsswissFineLineSliding Windows in Villa LakesideSuspension SystemsMetawellAluminum Panels for Smart CeilingsGlassDip-TechDigital Ceramic Printing in Roofs & CanopiesSound BoothsFrameryMeeting Pod – Framery Q – Flip n’ FoldWall / Ceiling LightsAsaf WeinbroomLighting – Linestra 110 BrassMore products »Save世界上最受欢迎的建筑网站现已推出你的母语版本!想浏览ArchDaily中国吗?是否翻译成中文现有为你所在地区特制的网站?想浏览ArchDaily中国吗?Take me there »✖You’ve started following your first account!Did you know?You’ll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my stream Save this picture!Courtesy of AART Architects+ 22Curated by María Francisca González Share “COPY” 2008center_img Area:  200 m² Year Completion year of this architecture project Home for Life / AART ArchitectsSave this projectSaveHome for Life / AART Architects Denmark Manufacturers Brands with products used in this architecture project Architects: AART Architects Area Area of this architecture project “COPY” Manufacturers: Cupa Pizarras, VELUX Commercial, Velfac Products translation missing: Year:  Houseslast_img read more

First months of lockdown saw public give extra £800m

first_img People in the UK gave £800 million more than usual to charity during the UK’s spring lockdown, but some causes missed out.According to a special UK Giving & Covid-19 report by the Charities Aid Foundation (CAF) into UK household giving, between January and June 2020, the public donated a total of £5.4 billion to charity – £800 million more than for the same period in 2019.CAF found that giving during these first months of lockdown was at levels normally seen during the peak seasonal fundraising months of November and December when the Poppy Appeal, Children in Need and major Christmas appeals are held. Advertisement First months of lockdown saw public give extra £800m In particular, there was a large increase in the number of people donating to or sponsoring ‘hospitals and hospices’ during the height of the pandemic’s first wave, while one in five people reported donating to charities which support the NHS.However, the report also shows that some charities suffered unprecedented losses. Medical research charities are among those hardest hit, losing an estimated £174 million in the first six months of 2020. Other causes that are normally among the most popular also experienced large drops in donations including animal charities and those supporting children and young people.Neil Heslop, Chief Executive at the Charities Aid Foundation, said:“There has never been a time in living memory when we have collectively been more aware of the value of charity in our lives and that is clearly borne out in this CAF report and in the generosity of the British people.“It is also our sincere hope that these extraordinary levels of giving serve as inspiration and reminds us of what is possible when people come together to support the causes closest to their hearts.“It is worth remembering that this is not about the charities themselves – at the end of the day it is about the causes they support, be they our neighbours, our friends, or our natural world. We need them all to survive and to thrive, for all of our sakes.”More key findings include:Cash donations saw a substantial drop off between March (34%) and April (13%) and remain at very low levels compared to previous years, reflecting halted charity tin collections, prize draws and other cash transactions.The number of people giving via a website or app increased significantly over the same period (from 13% to 24%) and this remains at much higher levels than normal.Trust in charities, which increased during 2019 after three years of decline, has increased further since March 2020. The improvement is seen across different age groups and social grades.The public reported feeling anxious about their household finances early in the pandemic, although this did not result in giving less to charity.By the end of April more people than usual reported that they intended to donate more in the next 12 months (12% vs. a long term average of 7%) – a figure that remains elevated.  271 total views,  1 views today AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis3 Tagged with: COVID-19 Research / statisticscenter_img Melanie May | 29 October 2020 | News AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis3 About Melanie May Melanie May is a journalist and copywriter specialising in writing both for and about the charity and marketing services sectors since 2001. She can be reached via read more

State Officials See Conservation in Action

first_imgThe Eagle Creek Watershed is part of the Upper White River Watershed and drains into Eagle Creek Reservoir, which serves as a public drinking water supply for Indianapolis.  The watershed has a Hydrologic Unit Code (HUC) of 05120201120 and has a drainage area of 162 square miles north of the Eagle Creek Dam located approximately 10 miles northwest of downtown Indianapolis.  The watershed runs through parts of Boone, Hamilton, Hendricks, and Marion Counties.  The dominant land-cover is agriculture with some portions of the watershed, particularly those closest to the reservoir, undergoing increased urbanization.Audio Player Up/Down Arrow keys to increase or decrease volume.Podcast: Play in new window | Download | EmbedSubscribe: RSS By Gary Truitt – May 31, 2012 SHARE Joe KelsayTop state officials got a chance to see on-farm conservation up close on Thursday. ISDA Director Joe Kelsay and Division of Soil and Water conservation staff saw conservation practices in action on two farms in Hendricks County.  Kelsay said this is an example of what can be accomplished when farmers and state and federal agencies work together, “The purpose of what we are doing today is to see real action on the ground and see how the partners are working together.” He added these site are good examples of what farmers can do to improve conservation and soil health on their land. Facebook Twitter Facebook Twitter Using state-of-the-art technology on the Starkey and Maloney farms, a 60 foot wide grass waterway has been constructed as part of the Eagle Creek Watershed.  Kelsay said this is a prime example of how it should be done, “This is a nice display of what doing it right should look like.”  He told HAT this watershed is important because it impacts the drinking water supply for Indianapolis, “But we have a group of farmers who are committed to conservation and have found a way to benefit the environment but also benefit their operations.”  While at the site, Kelsay was put to work using laser technology to measure the specifications of the waterway to make sure it had been constructed within the guidelines. Special netting was used to hold the soil in place while grass was being grown.center_img Previous articleKnee High Corn on Memorial DayNext articleHot, Dry May Brings Drought To Parts Of Indiana Gary Truitt Home News Feed State Officials See Conservation in Action SHARE State Officials See Conservation in Action ISDA Division of Conservation DirectorJerod Chew says this there are funds and technical assistance through CREP and CRP that can help farmers make this kind of investment in their land, “These are programs that are underutilized in the state.” He said there is technical and financial assistance available for farmers who want to make this kind of improvement to their land.  In addition, the group visited a 4.5 acre forest buffer constructed with CREP funding and a 23.7 acre CRP Safe Planting area.[audio:|titles=State Officials See Conservation in Action]WHAT IS THE EAGLE CREEK WATERSHED?last_img read more

Enhance Your Children’s Summer Experience with Engaging Virtual Programs

first_imgWhen the Institute for Educational Advancement (IEA) made the difficult decision to cancel all in-person summer programming, the organization knew they had to find ways to connect with their students virtually instead. As a non-profit that supports all aspects of a gifted child, IEA is very aware of the extreme toll this pandemic has taken on the intellectual, social and emotional wellbeing of students and their families. IEA’s parents and students were eager for the organization to provide quality material in safe learning environments that engage our young people intellectually and channel their intensities and anxieties in healthy ways.“Our kids look forward to joining us each summer at our Learning Center in Pasadena and at our Yunasa camps” said Elizabeth D. Jones, President & Co-Founder of IEA. “While we knew we could bring our existing content online, we also challenged staff to go further and think of ways we could ensure our community can connect with one another, even from a distance.”IEA’s small but mighty staff and faculty quickly created compelling online content and provided virtual spaces for communities to come together. This summer, IEA will continue to offer advanced learning and social opportunities virtually.In addition to online Academy classes and virtual Yunasa summer camps, families can sign up now for IEA’s new Spyglass workshops, which use a digital platform to bring high-level content into the homes of gifted and advanced students across the country. Spyglass will consist of live, interactive sessions, both standalone and in series, on a variety of topics for a range of ages.This summer, students can sign up for workshops like the highly relevant series Digital Civic, Changemakers of Tomorrow, which will challenge students to identify reliable sources versus misinformation, utilize effective strategies for communicating information and create impactful media content. Students will be encouraged to work together to apply these skills through projects that raise awareness of causes important to them and their communities. Other Spyglass series scheduled include Critical Studies of Science Fiction, College and Career Readiness and Introduction to Speech and Debate.Families have already found these resources extremely helpful. As one IEA parent stated, “We have only been able to engage with IEA through camp Yunasa. The online content tailored to gifted kids that IEA is planning to offer is a huge bright spot for me coming out of this awful experience! We can't get this type of content otherwise.”Sign up now for any of the classes online at or call IEA at (626) 403-8900 to learn more about these programs. Together, we can ensure our students are able to continue to grow both mentally and interpersonally this distanced summer.For more information about IEA’s other programs and services, visit Institute for Educational AdvancementThe Institute for Educational Advancement (IEA) is dedicated to the intellectual, creative, and personal growth of our nation’s gifted and high potential youth. Central to the mission of IEA is a commitment to the development of the whole child through engaging educational experiences that promote optimal challenge, mentorship, exploration of ideas, and recognition of personal potential. IEA seeks to connect like-minded individuals through dynamic and engaging year-round programming. Additionally, IEA supports a diverse community that creates a sense of belonging and affirmation. For more information, visit Name (required)  Mail (required) (not be published)  Website  76 recommended0 commentsShareShareTweetSharePin it Top of the News Your email address will not be published. Required fields are marked * Make a comment CITY NEWS SERVICE/STAFF REPORT Pasadena Will Allow Vaccinated People to Go Without Masks in Most Settings Starting on Tuesday Community News More Cool Stuff faithfernandez More » ShareTweetShare on Google+Pin on PinterestSend with WhatsApp,PCC – EducationVirtual Schools PasadenaDarrell Done EducationHomes Solve Community/Gov/Pub SafetyPASADENA EVENTS & ACTIVITIES CALENDARClick here for Movie Showtimes Home of the Week: Unique Pasadena Home Located on Madeline Drive, Pasadenacenter_img Community News EVENTS & ENTERTAINMENT | FOOD & DRINK | THE ARTS | REAL ESTATE | HOME & GARDEN | WELLNESS | SOCIAL SCENE | GETAWAYS | PARENTS & KIDS STAFF REPORT First Heatwave Expected Next Week Get our daily Pasadena newspaper in your email box. Free.Get all the latest Pasadena news, more than 10 fresh stories daily, 7 days a week at 7 a.m. Business News STAFF REPORT Pasadena’s ‘626 Day’ Aims to Celebrate City, Boost Local Economy HerbeautyWant To Seriously Cut On Sugar? You Need To Know A Few TricksHerbeautyHerbeautyHerbeautyAncient Beauty Remedies From India To Swear By For Healthy SkinHerbeautyHerbeautyHerbeauty6 Lies You Should Stop Telling Yourself Right NowHerbeautyHerbeautyHerbeautyTiger Woods Is ‘Different Man’ 10 Years After ScandalHerbeautyHerbeautyHerbeautyAmazing Sparks Of On-Screen Chemistry From The 90-sHerbeautyHerbeautyHerbeautyStop Eating Read Meat (Before It’s Too Late)HerbeautyHerbeauty Subscribe Education Enhance Your Children’s Summer Experience with Engaging Virtual Programs This summer’s ever changing landscape provides children and youth of all ages an opportunity to participate in fun, challenging learning through IEA’s virtual programs STAFF REPORT Published on Tuesday, June 16, 2020 | 11:35 amlast_img read more

U.S. FDA Accepts for Priority Review Pfizer’s Application for TicoVac™ (Tick-borne Encephalitis Vaccine)

first_img Twitter U.S. FDA Accepts for Priority Review Pfizer’s Application for TicoVac™ (Tick-borne Encephalitis Vaccine) WhatsApp Facebook Facebook NEW YORK–(BUSINESS WIRE)–Feb 23, 2021– Pfizer Inc. (NYSE:PFE) today announced that the U.S. Food and Drug Administration (FDA) accepted for Priority Review the company’s Biologics License Application (BLA) for TicoVac™, its tick-borne encephalitis (TBE) vaccine for active immunization to prevent TBE in individuals 1 year of age and older. 1,2 If approved, TicoVac would be the first vaccine in the U.S. to help protect adults and children who are visiting or living in TBE endemic areas. In line with Priority Review designation, the FDA will target an action within six months of the application submission date, 3 with the anticipated Prescription Drug User Fee Act (PDUFA) action date expected for August 2021. TBE is a viral infection of the brain and spine, 4 which is transmitted to humans through the bite of an infected tick. 5 To date, ticks infected with the TBE virus have been identified in more than 35 countries across Europe and Asia. 5 The European Centre for Disease Prevention and Control (ECDC) currently recommends TBE vaccination for people who live in or are traveling to these risk areas. 6 “For many years, our TBE vaccine has helped protect millions of people in Europe from this potentially serious disease. We are proud that today’s U.S. FDA Priority Review acceptance acknowledges the potential value that our vaccine candidate can bring,” said Nanette Cocero, Ph.D., Global President, Vaccines, Pfizer Inc. “If approved in the U.S., we hope this vaccine will help protect those traveling to or residing temporarily in at-risk locations, potentially including military personnel who are serving overseas.” The BLA is based on results from more than 40 years of experience and evidence outside the U.S. 7 In clinical trials, the safety and immunogenicity of TicoVac was assessed across two age groups (1-15 years of age and 16-65 years of age). 7 In these studies, pooled seropositivity rates were 99-100% in 1-15 year olds and 94-99% in adults >15 years following three doses. *8,9 Clinical studies demonstrated that TicoVac was well-tolerated with no unexpected adverse events or vaccine-related serious adverse events observed. 8,9 Subsequent real-world studies have shown that the vaccine is 96-99% effective in people who have received at least two doses of the vaccine, 10,11 and two to three doses of the vaccine were shown to be sufficient to provide a long-lasting immune memory. 1,2,12 About TicoVac™ (TBE vaccine, whole virus inactivated) Pfizer’s TBE vaccine, marketed under the brand names TicoVac and FSME-Immun™ in Europe, is an inactivated whole virus vaccine developed using a master ‘seed’ virus that is similar to the TBE virus found in nature. 13 Therefore, it is able to induce neutralizing antibodies against the natural TBE virus, as the sequence and structure of the virus subtype match those found in nature. 14 The vaccine helps provide protection against all known subtypes of the TBE virus in both children (from one year of age) and adults, 1,2,14 including the European, Siberian and Far Eastern subtypes. 15,16 More than 40 years of experience with the Pfizer TBE vaccine exist outside the U.S., and more than 160 million doses of the vaccine have been distributed since 1976. 7,17 About TBE TBE is a viral infection of the brain and spine, 4 transmitted to humans through the bite of an infected tick, 5 and less frequently by ingestion of unpasteurized milk or milk products from infected animals. 4 It may initially be mistaken for summer flu, 18,19 but can be a serious condition with possible long-term consequences. 4,19 More than 1 in 3 people can have long-term effects that last months or years including cognitive changes, muscle weakness or permanent paralysis, 4,19 and in rare cases (0.5-2%; up to 20% in Russia), people may die. 20,21 TBE can affect people of all ages who come into contact with ticks whenever they do outdoor activities in countries where ticks infected with TBE are prevalent. 4,21 Although TBE is not endemic in the U.S., TBE has been reported in more than 35 countries, ranging from Western Europe to Japan. 5 Currently there is no cure or treatment for TBE, only management of symptoms. 4 The potential vaccine could help protect people from the U.S. who are traveling to or living in endemic regions. About Pfizer: Breakthroughs That Change Patients’ Lives At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world’s premier innovative biopharmaceutical companies, we collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world. For more than 170 years, we have worked to make a difference for all who rely on us. We routinely post information that may be important to investors on our website at In addition, to learn more, please visit us on and follow us on Twitter at @Pfizer and @Pfizer News, LinkedIn, YouTube and like us on Facebook at DISCLOSURE NOTICE:The information contained in this release is as of February 23, 2021. Pfizer assumes no obligation to update forward‐looking statements contained in this release as the result of new information or future events or developments. This release contains forward‐looking information about Pfizer’s tick-borne encephalitis (TBE) vaccine, including and a potential indication in the U.S. for active immunization to prevent TBE in individuals 1 year of age and older and its potential benefits, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, the uncertainties inherent in research and development, including the ability to meet anticipated clinical endpoints, commencement and/or completion dates for our clinical trials, regulatory submission dates, regulatory approval dates and/or launch dates, as well as the possibility of unfavorable new clinical data and further analyses of existing clinical data; the risk that clinical trial data are subject to differing interpretations and assessments by regulatory authorities; whether regulatory authorities will be satisfied with the design of and results from our clinical studies; whether and when any biologics license applications may be filed in any other jurisdictions for Pfizer’s TBE vaccine; whether and when the BLA pending in the U.S. may be approved and whether and when any such other applications may be approved by regulatory authorities, which will depend on myriad factors, including making a determination as to whether the product’s benefits outweigh its known risks and determination of the product’s efficacy and, if approved, whether Pfizer’s TBE vaccine will be commercially successful; decisions by regulatory authorities impacting labeling, manufacturing processes, safety and/or other matters that could affect the availability or commercial potential of Pfizer’s TBE vaccine; uncertainties regarding the ability to obtain recommendations from vaccine technical committees and other public health authorities regarding Pfizer’s TBE vaccine and uncertainties regarding the commercial impact of any such recommendations; the impact of COVID-19 on our business, operations and financial results; and competitive developments. A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2019 and in its subsequent reports on Form 10-Q, including in the sections thereof captioned “Risk Factors” and “Forward-Looking Information and Factors That May Affect Future Results”, as well as in its subsequent reports on Form 8-K, all of which are filed with the U.S. Securities and Exchange Commission and available at and ReferencesTicoVac ® Summary of Product Characteristics. Last updated: November 2018.TicoVac ® Junior Summary of Product Characteristics. Last updated: November 2018.U.S Food & Drug Administration. Priority Review. Available from: Accessed: February 2021.Lindquist L, et al. Tick-borne encephalitis. The Lancet. 2008;371(9627):1861-71.Dobler G, Erber W, Bröker M, Schmitt HJ, eds. The TBE Book. 3 rd ed. Singapore: Global Health Press; 2020. doi:10.33442/26613980—1-3. Available from: Accessed: May 2020.European Centre for Disease Prevention and Control. Key messages about tick-borne encephalitis and tick-borne diseases. Available from: Accessed: February 2021.Loew-Baselli A, et al. Prevention of tick-borne encephalitis by FSME-IMMUN vaccines: review of a clinical development programme. Vaccine. 2011;29(43):7307-19.Ehrlich HJ, et al. Randomized, phase II dose-finding studies of a modified tick-borne encephalitis vaccine: evaluation of safety and immunogenicity. Vaccine. 2003 Dec 12;22(2):217-23.Pöllabauer EM, et al. Clinical evaluation to determine the appropriate paediatric formulation of a tick-borne encephalitis vaccine. Vaccine. 2010 Jun 23;28(29):4558-65.Heinz FX, et al. Field effectiveness of vaccination against tick-borne encephalitis. Vaccine. 2007;25(43):7559-67.Heinz FX, et al. Vaccination and tick-borne encephalitis, central Europe. Emerg Infect Dis. 2013;19(1):69-76.Schosser R, et al. Irregular tick-borne encephalitis vaccination schedules: the effect of a single catch-up vaccination with FSME-IMMUN®. A prospective non-interventional study. Vaccine. 2014;32(20):2375-81.Barrett PN. Tick-borne encephalitis virus vaccines, p 773–88. In: Plotkin SA, Orenstein WA, PA O, (ed). Vaccines Sixth edition. Elsevier Saunders; 2013, Philadelphia, PA.Orlinger KK, et al. A tick-borne encephalitis virus vaccine based on the European prototype strain induces broadly reactive cross-neutralizing antibodies in humans. J Infect Dis. 2011;203(11):1556-64.Adelshin RV, et al. Complete Genome Sequences of Four European Subtype Strains of Tick-Borne Encephalitis Virus from Eastern Siberia, Russia. Genome Announc. 2015;3(3).Tonteri E, et al. Tick-borne encephalitis virus in wild rodents in winter, Finland, 2008-2009. Emerg Infect Dis. 2011;17(1):72-5.Pfizer. Data on file. 2020 FSME-IMMUN doses.Travel Health Pro. Country information. Tick borne encephalitis. Available from: Accessed: February 2021.Kaiser R. Tick-borne encephalitis. Infect Dis Clin North Am. 2008;22(3):561-75.Santos R., Monteiro S. Epidemiology, control, and prevention of emerging zoonotic viruses. Viruses in Food and Water. 2013:442-457.European Centre for Disease Prevention and Control. Factsheet about tick-borne encephalitis. Available from: Accessed: February 2021. * Seropositivity measured by neutralizing antibody titers (NT) and enzyme-linked immunosorbent assay (ELISA) responses. View source version on CONTACT: Media Contact: Steve Danehy +1 (212) 733-1538 [email protected] Investor Contact: Bryan Dunn +1 (212) 733-8917 [email protected] KEYWORD: NEW YORK EUROPE UNITED STATES NORTH AMERICA ASIA PACIFIC INDUSTRY KEYWORD: INFECTIOUS DISEASES FDA PHARMACEUTICAL HEALTH SOURCE: Pfizer Inc. Copyright Business Wire 2021. 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Met Eireann warns of more thunderstorms on the way

first_img Facebook Met Eireann warns of more thunderstorms on the way Calls for maternity restrictions to be lifted at LUH WhatsApp Pinterest Twitter NPHET ‘positive’ on easing restrictions – Donnelly Facebook Met Eireann has issued an orange weather alert, with a thunderstorm warning in place for the entire country.The activity is expected this evening and overnight, with parts of Donegal already seeing some very heavy rain today, sometimes accompanied by thunder and lightning.Some intense thundery downpours are likely at times, with flash flooding also forecast.Forecaster with Met Eireann, Pat Clarke, says all areas may be at risk tomorrow……….Audio Player Up/Down Arrow keys to increase or decrease volume. RELATED ARTICLESMORE FROM AUTHOR Previous articleA Million Ways to Die in the WestNext articlePat Finucane Centre in Derry seeking early meeting with new Chief Constable over Good Samaritan bomb News Highland Google+center_img Google+ By News Highland – June 9, 2014 Twitter Three factors driving Donegal housing market – Robinson WhatsApp Guidelines for reopening of hospitality sector published News LUH system challenged by however, work to reduce risk to patients ongoing – Dr Hamilton Pinterest Almost 10,000 appointments cancelled in Saolta Hospital Group this weeklast_img read more